Literature summary for 3.1.4.59 extracted from

Corrigan, R.; Abbott, J.; Burhenne, H.; Kaever, V.; Gruendling, A.
C-di-amp is a new second messenger in staphylococcus aureus with a role in controlling cell size and envelope stress (2011), PLoS Pathog., 7, e1002217 .

Search for more literature for 3.1.4.59

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-
Staphylococcus aureus RN4220	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclic di-3',5'-adenylate + H2O	-	Staphylococcus aureus	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?
cyclic di-3',5'-adenylate + H2O	-	Staphylococcus aureus RN4220	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?

Synonyms

Synonyms	Comment	Organism
gdpP	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	mutations within the GdpP gene, allow both laboratory and clinical isolates of Staphylococcus aureus to grow without lipoteichoic acid. Intracellular c-di-AMP levels increase drastically in GdpP deletion strains and in an lipoteichoic acid-deficient suppressor strain. An increased amount of cross-linked peptidoglycan is observed in the GdpP mutant strain. GdpP mutant strains display a 13-22% reduction in the cell size due to increased c-di-AMP levels	Staphylococcus aureus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)