Literature summary for 3.2.1.31 extracted from

Pollet, R.M.; DAgostino, E.H.; Walton, W.G.; Xu, Y.; Little, M.S.; Biernat, K.A.; Pellock, S.J.; Patterson, L.M.; Creekmore, B.C.; Isenberg, H.N.; Bahethi, R.R.; Bhatt, A.P.; Liu, J.; Gharaibeh, R.Z.; Redinbo, M.R.
An atlas of beta-glucuronidases in the human intestinal microbiome (2017), Structure, 25, 967-977.e5 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Bacteroides fragilis
-	Bacteroides ovatus
-	Bacteroides uniformis
-	Clostridium perfringens
-	Streptococcus agalactiae
-	Lachnospira eligens
-	Parabacteroides merdae
-	Phocaeicola dorei

Organism

Organism	UniProt	Comment	Textmining
Bacteroides fragilis	-	-	-
Bacteroides ovatus	-	-	-
Bacteroides uniformis	-	-	-
Clostridium perfringens	Q8XP19	-	-
Clostridium perfringens 13	Q8XP19	-	-
Lachnospira eligens	-	-	-
Parabacteroides merdae	-	-	-
Phocaeicola dorei	-	-	-
Streptococcus agalactiae	A0A0H1IHR6	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bacteroides fragilis
-	Bacteroides ovatus
-	Bacteroides uniformis
-	Clostridium perfringens
-	Streptococcus agalactiae
-	Lachnospira eligens
-	Parabacteroides merdae
-	Phocaeicola dorei

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl beta-D-glucuronide + H2O	-	Bacteroides fragilis	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Bacteroides ovatus	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Bacteroides uniformis	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Clostridium perfringens	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Streptococcus agalactiae	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Lachnospira eligens	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Parabacteroides merdae	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Phocaeicola dorei	4-nitrophenol + beta-D-glucuronate	-	?
4-nitrophenyl beta-D-glucuronide + H2O	-	Clostridium perfringens 13	4-nitrophenol + beta-D-glucuronate	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5	-	-	Bacteroides fragilis
5	-	-	Bacteroides ovatus
5.5	-	-	Bacteroides uniformis
5.5	-	-	Parabacteroides merdae
6	-	-	Lachnospira eligens
6	-	-	Phocaeicola dorei
6.5	-	-	Lachnospira eligens
7.4	-	-	Streptococcus agalactiae

General Information

General Information	Comment	Organism
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Bacteroides fragilis
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Bacteroides ovatus
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Bacteroides uniformis
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Clostridium perfringens
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Streptococcus agalactiae
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Lachnospira eligens
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Parabacteroides merdae
metabolism	microbiome-encoded beta-glucuronidase enzymes play important roles in human health by metabolizing drugs in the gastrointestinal tract	Phocaeicola dorei

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Release 2023.1 (January 2023)