Application | Comment | Organism |
---|---|---|
medicine | RB150 is the first oral active prodrug inhibiting brain but not systemic renin-angiotensin system activity, strongly reducing blood pressure several hours after a single administration | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-3-amino-4-mercaptobutyl sulfonic acid | EC33, specific and selective APA inhibitor | Mus musculus | |
(S)-3-amino-4-mercaptobutyl sulfonic acid | EC33, specific and selective APA inhibitor | Rattus norvegicus | |
4,4'-dithio[bis(3)-aminobutylsulfonic acid] | RB150, a prodrug of EC33 | Mus musculus | |
4,4'-dithio[bis(3)-aminobutylsulfonic acid] | RB150, a prodrug of EC33 | Rattus norvegicus | |
bestatin | broad specificity for various aminopeptidases | Mus musculus | |
bestatin | broad specificity for various aminopeptidases | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Mus musculus | |
Zn2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
hypertensive DOCA-salt rat, for the on vitro activity assay recombinant mouse APA is used | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000686 | - |
DOCA-salt rat, 30 mg/kg RB150, 3.5 h after po | Rattus norvegicus |
0.00071 | - |
DOCA-salt rat, 50 mg/kg RB150, 3.5 h after po | Rattus norvegicus |
0.000726 | - |
DOCA-salt rat, 15 mg/kg RB150, 3.5 h after po | Rattus norvegicus |
0.000728 | - |
normotensive WKY rat, 15 mg/kg RB150, 3.5 h after po | Rattus norvegicus |
0.000752 | - |
normotensive WKY rat, 3.5 h after administration of saline po | Rattus norvegicus |
0.00077 | - |
normotensive Sham rat, 3.5 h after administration of saline po | Rattus norvegicus |
0.001083 | - |
DOCA-salt rat, 7.5 mg/kg RB150, 3.5 h after po | Rattus norvegicus |
0.001525 | - |
DOCA-salt rat, 3.5 h after administration of saline po | Rattus norvegicus |
0.001557 | - |
DOCA-salt rat, 15 mg/kg RB150, 24 h after po | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | aspartic acid + angiotensin III | angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
Glu-2-naphthylamide + H2O | synthetic substrate used in the activity assay | Mus musculus | Glu + 2-naphthylamine | - |
? | |
Glu-2-naphthylamide + H2O | synthetic substrate used in the activity assay | Rattus norvegicus | Glu + 2-naphthylamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Mus musculus |
aminopeptidase A | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay | Mus musculus |
7.4 | - |
activity assay | Rattus norvegicus |