Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyemodin 1-methylether | 47.52% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
alaternin | 24.26% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
captopril | 87.87% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
emodin | 45.79% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
gluco-aurantioobtusin | competitive inhibitor, 137.62% inhibition at 1.63 ng/ml | Oryctolagus cuniculus | |
additional information | ACE is not inhibited by gluco-obtusifolin, obtusifolin, aurantioobtusin, cassitoroside, toralactone gentiobioside, chrysophanol triglucoside, questin, and cassiaside; both of the methanol extracts from the raw and roasted Cassia tora seeds exhibit significant inhibitory properties against ACE, demonstrating more than 50% inhibition at a concentration of 0.16393 mg/ml | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Oryctolagus cuniculus | - |
angiotensin II + L-His-L-Leu | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Oryctolagus cuniculus | angiotensin II + L-His-L-Leu | - |
? | |
N-[3-(2-furyl)acryloyl]-L-Phe-Gly-Gly + H2O | - |
Oryctolagus cuniculus | 2-furylacrylic acid + L-Phe-Gly-Gly | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE | - |
Oryctolagus cuniculus |
angiotensin-converting enzyme | - |
Oryctolagus cuniculus |
peptidyldipeptide hydrolase | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000083 | - |
gluco-aurantioobtusin | in 50 mM Tris-HCl buffer (pH 7.5) | Oryctolagus cuniculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03024 | - |
in 50 mM Tris-HCl buffer (pH 7.5) | Oryctolagus cuniculus | gluco-aurantioobtusin |