Data extracted from this reference:
Cloned(Commentary)
expressed in HEK-ACE2 cells
Homo sapiens
Inhibitors
additional information
GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2
Homo sapiens
Localization
plasma membrane
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu
Homo sapiens
5886
Organism
Substrates and Products (Substrate)
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O
679876
Homo sapiens
(7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys
?
angiotensin I + H2O
679876
Homo sapiens
angiotensin-(1-9) + Leu
?
angiotensin II + H2O
679876
Homo sapiens
angiotensin-(1-7) + Phe
?
additional information
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane
679876
Homo sapiens
?
Synonyms
angiotensin-converting enzyme-2
Homo sapiens
Cloned(Commentary) (protein specific)
expressed in HEK-ACE2 cells
Homo sapiens
Inhibitors (protein specific)
additional information
GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2
Homo sapiens
Localization (protein specific)
plasma membrane
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu
Homo sapiens
5886
Substrates and Products (Substrate) (protein specific)
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O
679876
Homo sapiens
(7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys
?
angiotensin I + H2O
679876
Homo sapiens
angiotensin-(1-9) + Leu
?
angiotensin II + H2O
679876
Homo sapiens
angiotensin-(1-7) + Phe
?
additional information
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane
679876
Homo sapiens
?
Other publictions for EC 3.4.17.23