BRENDA - Enzyme Database
show all sequences of 3.4.17.23

Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

Lambert, D.W.; Clarke, N.E.; Hooper, N.M.; Turner, A.J.; FEBS Lett. 582, 385-390 (2008)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in HEK-ACE2 cells
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu
Homo sapiens
5886
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O
-
679876
Homo sapiens
(7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys
-
-
-
?
angiotensin I + H2O
-
679876
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
?
angiotensin II + H2O
-
679876
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
additional information
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane
679876
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
ACE2
-
Homo sapiens
angiotensin-converting enzyme-2
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in HEK-ACE2 cells
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
plasma membrane
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu
Homo sapiens
5886
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O
-
679876
Homo sapiens
(7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys
-
-
-
?
angiotensin I + H2O
-
679876
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
?
angiotensin II + H2O
-
679876
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
additional information
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane
679876
Homo sapiens
?
-
-
-
-
Other publictions for EC 3.4.17.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)