Activating Compound | Comment | Organism | Structure |
---|---|---|---|
vitamin K | dependent on, activation cycle, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the enzyme is clinically used to treat hemophilia, clinical trials, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genetic localization at 13q34, cloning from a liver gene library, expression in BHK cells with secretion to the medium | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | one FVIIa molecule binds 8 Ca2+ in the epidermal growth factor-like and the gamma-carboxyglutamic acid-rich domains | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, zymogen FVII, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor X + H2O | Homo sapiens | the enzyme is involved in the coagulation cascade, pathways, overview | Factor Xa + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylation at Asp145 and Asp322, and O-glycosylation | Homo sapiens |
proteolytic modification | zymogen factor VII is activated by thrombin | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant FVII zymogen from BHK cell medium | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
Factor X + H2O | the enzyme is involved in the coagulation cascade, pathways, overview | Homo sapiens | Factor Xa + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, zymogen FVII, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
factor VIIa | - |
Homo sapiens |
FVIIa | - |
Homo sapiens |
vitamin K dependent clotting factor | - |
Homo sapiens |