Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PSA-alpha1-antichymotrypsin complex is cleared from the blood, but as its concentration increases its clearance mechanism becomes saturated and only then do the PSA-alpha1-antichymotrypsin complexes accumulate in the blood | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | urine detection of the PSA activation peptide may represent a clinically sensitive measure of PSA production/secretion and may prove to be a viable alternative/addition to current PSA assays | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
x * 36000, SDS-PAGE, pro-PSA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by centrifugation and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
urine | activation peptide of PSA is filtered from the bloodstream by the kidney, and is detectable in the urine of patients with prostate cancer, but not controls. Serum PSA concentration is dependent on how much PSA gains access to the bloodstream and how efficiently it is removed | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 36000, SDS-PAGE, pro-PSA | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
prostate-specific antigen | - |
Homo sapiens |
PSA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PSA is secreted as an inactive pro-enzyme containing an N-terminal seven amino acid (Ala-Pro-Leu-Ile-Leu-Ser-Arg) activation peptide, which is removed extracellularly in vivo | Homo sapiens |