Activating Compound | Comment | Organism | Structure |
---|---|---|---|
chondroitin 4-sulfate | activates 2fold in 24 h | Homo sapiens | |
chondroitin 6-sulfate | activates 2.5fold in 24 h | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of procathepsin K in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-873724 | a cathepsin K inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen II + H2O | Homo sapiens | cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage | ? | - |
? | |
additional information | Homo sapiens | generation of a C-terminal neoepitope, C2K, in triple-helical type II collagen by the proteolytic action of cathepsin K, the optimal concentration of cathepsin K for generation of C2K neoepitope is 0.01 mM, effects of its presence in normal adult and osteoarthritic femoral condylar articular cartilage, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant procathepsin K from Pichia pastoris, processed to the mature form and purified | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | osteoarthritic and nonarthritic femoral condylar articular, and normal articular | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen II + H2O | cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage | Homo sapiens | ? | - |
? | |
collagen II + H2O | human, the cleavage site is GEAGKPG_KAGERGPPG | Homo sapiens | ? | - |
? | |
additional information | generation of a C-terminal neoepitope, C2K, in triple-helical type II collagen by the proteolytic action of cathepsin K, the optimal concentration of cathepsin K for generation of C2K neoepitope is 0.01 mM, effects of its presence in normal adult and osteoarthritic femoral condylar articular cartilage, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | cysteine protease of the papain family | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 7 | collagen II cleaving activity | Homo sapiens |