Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-bound endopeptidase | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | Mus musculus | - |
? | - |
? | |
angiotensin II + H2O | Mus musculus | - |
? | - |
? | |
bradykinin + H2O | Mus musculus | - |
? | - |
? | |
dynorphin A(1-8) + H2O | Mus musculus | - |
? | - |
? | |
hemopressin + H2O | Mus musculus | - |
? | - |
? | |
metorphamide + H2O | Mus musculus | - |
? | - |
? | |
neurotensin + H2O | Mus musculus | - |
? | - |
? | |
somatostatin + H2O | Mus musculus | - |
? | - |
? | |
Substance P + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | membrane preparations of frontoparietal cortex, striatum, and hippocampus isolated from the ischemic hemisphere of mouse brain 24 h after reperfusion reveal a statistically significant over 2fold increase in quantity and activity of neurolysin compared with sham-operated controls, no effect on the cerebellar enzyme activity. Functional up-regulation of neurolysin in frontoparietal cortical membranes for at least 7 days after stroke appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria | Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
frontoparietal cortex | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin I + H2O | - |
Mus musculus | ? | - |
? | |
angiotensin II + H2O | - |
Mus musculus | ? | - |
? | |
bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
dynorphin A(1-8) + H2O | - |
Mus musculus | ? | - |
? | |
hemopressin + H2O | - |
Mus musculus | ? | - |
? | |
metorphamide + H2O | - |
Mus musculus | ? | - |
? | |
neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
somatostatin + H2O | - |
Mus musculus | ? | - |
? | |
Substance P + H2O | - |
Mus musculus | ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Mus musculus | membrane-bound endopeptidase neurolysin is up-regulated in different parts of mouse brain affected by focal ischemia-reperfusion in a middle cerebral artery occlusion model of stroke, up-regulation of neurolysin occurs in post-ischemic brain regions | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in peptidergic systems that play a role in pathogenesis of stroke and resistance to ischemic injury and/or post-stroke brain recovery. Neurolysin may play a role in processes modulating the brain's response to stroke and its recovery after stroke | Mus musculus |