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Literature summary for 3.4.24.30 extracted from

  • Makinen, K.K.; Makinen, P.
    Coccolysin (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 396-398.
No PubMed abstract available
Search for more literature for 3.4.24.30

Application

Application Comment Organism
medicine coccolysin is a virulence factor Enterococcus faecalis

Inhibitors

Inhibitors Comment Organism Structure
high molecular mass inflammatory factor
-
 Enterococcus faecalis
metal chelator inactivates Enterococcus faecalis
o-Chloranil is a near-stoichiometric inhibitor of the enzyme Enterococcus faecalis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Enterococcus faecalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31500
-
-
 Enterococcus faecalis

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
 var. liquefaciens, straom OG1-10
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Enterococcus faecalis ?
-
 ?
angiotensin II + H2O only cleaved at Tyr-Ile Enterococcus faecalis ?
-
 ?
Azocoll + H2O
-
 Enterococcus faecalis ?
-
 ?
bradykinin + H2O
-
 Enterococcus faecalis ?
-
 ?
casein + H2O
-
 Enterococcus faecalis ?
-
 ?
clots milk + H2O
-
 Enterococcus faecalis ?
-
 ?
Gelatin + H2O
-
 Enterococcus faecalis ?
-
 ?
Hemoglobin + H2O
-
 Enterococcus faecalis ?
-
 ?
human endothelin 1 + H2O
-
 Enterococcus faecalis ?
-
 ?
insulin B chain + H2O rapidly hydrolyzed at Phe24-Phe25, followed by the cleavage of the His5-Leu6 and other bonds Enterococcus faecalis ?
-
 ?
additional information no cleavage of Pz-Pro-Leu-Gly-Pro-D-Arg and 2-FA-Leu-Gly-Pro-Ala Enterococcus faecalis ?
-
 ?
pheromone related peptide + H2O
-
 Enterococcus faecalis ?
-
 ?
Substance P + H2O
-
 Enterococcus faecalis ?
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Enterococcus faecalis

Synonyms

Synonyms Comment Organism
metalloendopeptidase II
-
 Enterococcus faecalis
microbial proteinase
-
 Enterococcus faecalis
streptococcal gelatinase
-
 Enterococcus faecalis

pH Range

pH Minimum pH Maximum Comment Organism
6 8 with azocoll as substrate Enterococcus faecalis
7 7.2 with shorter peptides as substrates Enterococcus faecalis