Application | Comment | Organism |
---|---|---|
medicine | the Alzheimer's beta-amyloid peptide is degraded by the enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Rattus norvegicus | |
adrenocorticotropic hormone | competitive inhibition of amylin degradation | Rattus norvegicus | |
amylin | excess amylin inhibits amylin degradation, competitive inhibition | Rattus norvegicus | |
Aprotinin | 22.4% inhibition | Rattus norvegicus | |
atrialnatriuretic peptide | competitive inhibition of amylin degradation | Rattus norvegicus | |
bacitracin | - |
Rattus norvegicus | |
EDTA | 21% inhibition; 35.7% inhibition | Rattus norvegicus | |
glucagon | competitive inhibition of amylin degradation | Rattus norvegicus | |
Insulin | inhibits amylin degradation, excess insulin inhibits insulin degradation | Rattus norvegicus | |
additional information | pepstatin-A, leupeptin, and calpains are ineffective as inhibitors, no competitive inhibition with EGF or insulin C-peptide | Rattus norvegicus | |
N-ethylmaleimide | - |
Rattus norvegicus | |
PMSF | 14.4% inhibition | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
110000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
rat, Sprague-Dawley | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amylin + H2O | - |
Rattus norvegicus | ? | - |
? | |
beta-amyloid peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | EGF and insulin C-peptide are no substrates | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Rattus norvegicus |
Insulin-degrading enzyme | - |
Rattus norvegicus |