Application | Comment | Organism |
---|---|---|
medicine | secreted form of enzyme promotes carcinoma invasion through tumor-stromal interactions | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme expression in tumor cell lines induces a highly invasive phenotype, protease activity of enzyme is required for invasion | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatic stellate cell | cells secrete a alternatively spliced variant of enzyme promoting carcinoma invasion | Homo sapiens | - |
myofibroblast | stromal liver myofibroblast, enzyme expression particularly by cells localized within the tumor stroma at the invasive front | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Laminin + H2O | substrate of secreted form of enzyme | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme binds directly to alpha6beta4 and alpha2beta1 integrins through the disintegrin domain | Homo sapiens |