Cloned (Comment) | Organism |
---|---|
recombinant expression of adenoviral vector expressing the human acid ceramidase (Ad-ASAH1) gene in human OBA-9 cells. ASAH1-over-expressing OBA-9 cells show significantly lower mRNA expressions of caspase-3 as well as the percentage of Annexin V-positive cells, when compared to controls. In response to stimulation with Porphyromonas gingivalis, ASAH1-overexpressing OBA-9 cells produce less TNF-alpha, IL-6, and IL1beta pro-inflammatory cytokines than observed in OBA-9 cells transduced with Ad-control vector, quantitative real-time PCR expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13510 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
gingiva | a significantly lower level of acid ceramidase expression was detected in gingival tissues from periodontal patients compared to those from healthy subjects | Homo sapiens | - |
additional information | no significant fluctuation is detected for neutral or alkaline ceramidases in either gingival samples or cell cultures | Homo sapiens | - |
OBA-9 cell | immortalized gingival epithelial cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
ASAH1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | acid ceramidase expression in gingival cells is suppressed by stimulation with Porphyromonas gingivalis in vitro | down |
General Information | Comment | Organism |
---|---|---|
malfunction | a significantly lower level of acid ceramidase expression was detected in gingival tissues from periodontal patients compared to those from healthy subjects | Homo sapiens |
physiological function | endogenous acid ceramidase protects epithelial cells from Porphyromonas gingivalis (ATCC 33277)-induced inflammation in vitro. Anti-inflammatory and anti-apoptotic effects of acid ceramidase in host cells exposed to periodontal bacteria, and the attenuation of the expression of host-protective acid ceramidase in periodontal lesions | Homo sapiens |