Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydroxamic acid | hydroxamic acids are strong inhibitors of urease due to their chelating ability. They bind the Ni(II) centers present in the active site of urease in their anionic form via the (O,O) coordination mode. The Ni(II) centers of the urease active site are electrophilic in nature. This is responsible for appreciable charge transfer from the nucleophilic oxygen centers of the hydroxamate ligand to the Ni(II) centers when they bind in the active site. Hydroxamic acids with hydrophobic groups attached to them are more potent inhibitors of urease because they can easily penetrate the hydrophobic environment surrounding the active site. The -CONHO-x01moiety of the hydroxamic acid is also found to be absolutely necessary for chelation and inhibition of urease | Helicobacter pylori |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | P14916 | - |
- |
Helicobacter pylori ATCC 700392 | P14916 | - |
- |
Subunits | Comment | Organism |
---|---|---|
dodecamer | the enzyme consists of a spherical assembly composed of four (alphabeta)3 units having three-fold symmetry. It has a dodecameric ((alphabeta)3)4 architecture | Helicobacter pylori |