Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D102A/R106A | the mutant shows about 3% of wild type activity | Homo sapiens |
E33A | the mutant shows about 40% of wild type activity | Homo sapiens |
H30A | the mutant shows about 20% of wild type activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oxalate | potent competitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
oxaloacetate | at pH 7.4 and 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarylpyruvate + H2O | Homo sapiens | - |
fumarate + pyruvate + H+ | - |
? | |
oxaloacetate + H+ | Homo sapiens | - |
pyruvate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6P587 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarylpyruvate + H2O | - |
Homo sapiens | fumarate + pyruvate + H+ | - |
? | |
oxaloacetate + H+ | - |
Homo sapiens | pyruvate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 29000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FAH domain-containing protein 1 | - |
Homo sapiens |
FAHD1 | - |
Homo sapiens |
fumarylacetoacetate hydrolase domain-containing protein 1 | - |
Homo sapiens |
ODx | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
oxalate | at pH 7.4 and 25°C | Homo sapiens |