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Literature summary for 4.1.1.90 extracted from
- Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation (2011), J. Biol. Chem., 286, 7267-7278.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + CO2 + O2 + vitamin K hydroquinone | the enzyme uses oxygenation of vitamin K hydroquinone to vitamin K epoxide to drive the incorporation of CO2 into glutamyl residues to produce carboxylated glutamate in vitamin K-dependent proteins | Homo sapiens | gamma-carboxy L-glutamate + vitamin K epoxide + H2O | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-glutamyl carboxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin K | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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