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Literature summary for 4.2.1.1 extracted from

  • Cincinelli, A.; Martellini, T.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
    Purification and inhibition studies with anions and sulfonamides of an alpha-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii (2011), Bioorg. Med. Chem., 19, 1847-1851.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide
-
 Leptonychotes weddellii
azide
-
 Leptonychotes weddellii
benzolamide
-
 Leptonychotes weddellii
bicarbonate high inhibition Leptonychotes weddellii
brinzolamide
-
 Leptonychotes weddellii
bromide
-
 Leptonychotes weddellii
Carbonate high inhibition Leptonychotes weddellii
chloride
-
 Leptonychotes weddellii
Cyanate high inhibition Leptonychotes weddellii
cyanide high inhibition Leptonychotes weddellii
dichlorophenamide
-
 Leptonychotes weddellii
dorzolamide
-
 Leptonychotes weddellii
fluoride
-
 Leptonychotes weddellii
H2NSO2NH2
-
 Leptonychotes weddellii
H2NSO3H
-
 Leptonychotes weddellii
HSO3-
-
 Leptonychotes weddellii
hydrochlorothiazide
-
 Leptonychotes weddellii
Iodide
-
 Leptonychotes weddellii
methazolamide
-
 Leptonychotes weddellii
additional information no inhibition by perchlorate Leptonychotes weddellii
nitrate
-
 Leptonychotes weddellii
nitrite
-
 Leptonychotes weddellii
PhAsO3H2
-
 Leptonychotes weddellii
PhB(OH)2
-
 Leptonychotes weddellii
saccharin
-
 Leptonychotes weddellii
sulfamate
-
 Leptonychotes weddellii
sulfamide high inhibition Leptonychotes weddellii
sulfate
-
 Leptonychotes weddellii
Sulfide
-
 Leptonychotes weddellii
thiocyanate high inhibition Leptonychotes weddellii
zonisamide
-
 Leptonychotes weddellii

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ catalytically crucial Leptonychotes weddellii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 x * 30000, about, SDS-PAGE Leptonychotes weddellii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Leptonychotes weddellii
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Leptonychotes weddellii
-
 adult female Weddell seals
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Leptonychotes weddellii
-
intestine
-
 Leptonychotes weddellii
-
kidney
-
 Leptonychotes weddellii
-
liver
-
 Leptonychotes weddellii
-
lung
-
 Leptonychotes weddellii
-
spleen
-
 Leptonychotes weddellii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Leptonychotes weddellii CO2 + H2O
-
 r

Subunits

Subunits Comment Organism
? x * 30000, about, SDS-PAGE Leptonychotes weddellii

Synonyms

Synonyms Comment Organism
alpha-carbonic anhydrase
-
 Leptonychotes weddellii
lwCA
-
 Leptonychotes weddellii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
 assay at Leptonychotes weddellii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Leptonychotes weddellii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.046
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii PhB(OH)2
0.055
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii H2NSO3H
0.057
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii PhAsO3H2
0.06
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Carbonate
0.07
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii cyanide
0.07
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii H2NSO2NH2
0.087
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Cyanate
0.097
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii thiocyanate
0.1
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii bicarbonate
0.59
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii HSO3-
0.74
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii fluoride
0.82
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii sulfate
0.83
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii azide
0.89
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii chloride
0.9
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii nitrite
1
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Sulfide
1.01
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii bromide
20
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii Iodide
55.6
-
 pH 7.5, 20°C, inhibition of CO2 hydration activity Leptonychotes weddellii nitrate