Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(25S)-(+)-12alpha-hydroxy-3alpha-methylcarboxyacetate-24-methyllanosta-8,24(31)-diene-26-oic acid | from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0035 mM | Streptococcus agalactiae | |
3alpha-acetylpolyporenic acid A | from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.040 mM | Streptococcus agalactiae | |
lanostanoid | from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.051 mM | Streptococcus agalactiae | |
polyporenic acid | from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0125 mM | Streptococcus agalactiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronic acid | Streptococcus agalactiae | degradation of hyaluronate in connective tissue of hosts to facilitate invasion | hyaluronic acid oligomers | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus agalactiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronic acid | degradation | Streptococcus agalactiae | hyaluronic acid oligomers | - |
? | |
hyaluronic acid | degradation of hyaluronate in connective tissue of hosts to facilitate invasion | Streptococcus agalactiae | hyaluronic acid oligomers | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0035 | - |
from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0035 mM | Streptococcus agalactiae | (25S)-(+)-12alpha-hydroxy-3alpha-methylcarboxyacetate-24-methyllanosta-8,24(31)-diene-26-oic acid | |
0.0125 | - |
from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.0125 mM | Streptococcus agalactiae | polyporenic acid | |
0.04 | - |
from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.040 mM | Streptococcus agalactiae | 3alpha-acetylpolyporenic acid A | |
0.051 | - |
from Piptoporus betulinus inhibiting bacterial hyaluronate lyase, structure determination by NMR, IC50 is 0.051 mM | Streptococcus agalactiae | lanostanoid |