Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NO | activates the sGCalpha2beta1 enzyme and induces muscle relaxation after electric field stimulation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
the sGCalpha1 gene encodes for an essential part of the catalytic domain. Quantitative expression analysis by RT-PCR and relative levels of alpha1, alpha2, and beta1 subunit mRNA in male KO tissues versus male wild-type tissues | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of sGCalpha1 subunit KO mice, that show abolished muscle relaxation after electric field stimulation more pronounced in female than in male KO mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Mus musculus | role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview | 3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
female and male Swiss/129 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mus musculus | - |
jejunum | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
cGMP production in wild-type and sGCalpha1 KO mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | role of sGCalpha1beta1 in nitrergic regulation of jejunal smooth muscle activity in male and female mice, overview | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | alphabeta heterodimer, the sGCalpha1 subunit harbors an essential part of the catalytic domain | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Mus musculus |
sGCalpha2beta1 | - |
Mus musculus |
soluble guanylate cyclase | - |
Mus musculus |