Protein Variants | Comment | Organism |
---|---|---|
additional information | depletion of enzyme by siRNA reduces hormone-dependent transcription from both transfected reporters and an endogenous steroid receptor target gene. Depletion of enzyme in MCF-7 cells reduces the endogenous estrogen-dependent recruitment of p300 to the promoters of estrogen receptor-dependent genes. Enzyme overexpression enhances SRC-3 cellular turnover | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform Pin1, recombinant enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | breast cancer cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | selective for substrate SRC-3, phosphorylated steroid receptor coactivator 3. Enzyme and SRC-3 synergistically activate nuclear-receptor-regulated transcription | Homo sapiens | ? | - |
? |