Application | Comment | Organism |
---|---|---|
pharmacology | Pin1 is a potential therapeutic target in Rel/NF-kappaB-dependent leukemia/lymphomas | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a WW domain mutant of Pin1 can no longer interact with NF-kappaB | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
juglone | Pin1 inhibition leads to relocalization of endogenous c-Rel to the cytoplasm coincident with lymphoma cell death and/or growth inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Pin1 interacts with NF-kappaB via its WW domain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell lymphoma cell | - |
Homo sapiens | - |
carcinoma cell | the enzyme is upregulated in cancer cells | Homo sapiens | - |
KM-H2 cell | a Hodkin's lymphoma cell line | Homo sapiens | - |
lymphocyte | primary | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pin1 interacts with NF-kappaB via its WW domain | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl-prolyl isomerase | - |
Homo sapiens |
Pin1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is upregulated in cancer cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Pin1 markedly enhances transformation in primary lymphocytes by the c-Rel protein and by viral Rel/NF-kappaB oncoprotein v-Rel, it enhances the nuclear translocation of the Rel proteins, overview | Homo sapiens |