Literature summary for 5.2.1.8 extracted from

Shimizu, T.; Bamba, Y.; Kawabe, Y.; Fukuda, T.; Fujimori, F.; Takahashi, K.; Uchida, C.; Uchida, T.
Prolyl isomerase Pin1 regulates doxorubicin-inducible P-glycoprotein level by reducing Foxo3 stability (2016), Biochem. Biophys. Res. Commun., 471, 328-333 .

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Protein Variants

Protein Variants	Comment	Organism
R68/69A	mutant has lost the binding site to the phosphorylated Ser/Thre-Pro residues of substrates, still is able to decrease the transcriptional activity of FOXO3	Mus musculus
W34A	mutant lacks the WW motif of the FOXO3 binding site, is not able to decrease the transcriptional activity of FOXO3	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9QUR7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(cis)-Pro residue in protein FOXO3	-	Mus musculus	(trans)-Pro residue in protein FOXO3	-	r

Synonyms

Synonyms	Comment	Organism
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	-	Mus musculus
Pin1	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	In response to genotoxic drug doxorubicin, Pin1 binds and decreases levels of the phosphorylated Foxo3, the positive transcription factor of P-glycoprotein (P-gp) gene. Thereby, Pin1 decreases the level of P-gp and signals the cell to pump the genotoxic drugs out	Mus musculus

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Release 2023.1 (January 2023)