Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13526 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(cis)-Pro residue in HIF-1alpha | - |
Homo sapiens | (trans)-Pro residue in HIF-1alpha | - |
r |
General Information | Comment | Organism |
---|---|---|
physiological function | Pin1 interacts with hypoxia-inducible transcription factor HIF-1alpha. The interaction is regulated through p42/p44 MAPK pathway activation, and Pin1 catalytic activity generates a conformational change in HIF-1alpha. Pin1 is required for gene-specific HIF-1 transcriptional activity | Homo sapiens |