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Literature summary for 5.3.3.12 extracted from

  • Merk, M.; Zierow, S.; Leng, L.; Das, R.; Du, X.; Schulte, W.; Fan, J.; Lue, H.; Chen, Y.; Xiong, H.; Chagnon, F.; Bernhagen, J.; Lolis, E.; Mor, G.; Lesur, O.; Bucala, R.
    The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) (2011), Proc. Natl. Acad. Sci. USA, 108, E577-E585.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydoxyphenylpyruvate
-
 Homo sapiens ?
-
 ?
D-dopachrome
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Macrophage migration inhibitory factor
-
 Homo sapiens
MIF
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme binds to the type II transmembrane protein, CD74, leading to its intracellular phosphorylation, the recruitment of the coreceptor CD44, and the activation of SRC family kinases and the ERK1/2 MAPK pathway. The enzyme counterregulates the inhibitory effect of glucocorticoids on tissue necrosis factor production from lipopolysaccharide-stimulated macrophages Homo sapiens