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Literature summary for 5.6.2.2 extracted from
- Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis (2013), Antioxid. Redox Signal., 18, 1129-1140.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| etoposide | VP-16, induces skin melanomas formation in 7,12-dimethyl-benz[a]anthracene-initiated mice | Mus musculus |  |
| nitric oxide | NO, unlike VP-16, preferentially induces the formation of TOP2beta cleavable complexes in cells, induces skin melanomas formation in 7,12-dimethyl-benz[a]anthracene-initiated mice | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanoma cell | - |
Mus musculus | - |
| skin | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Top2 | - |
Mus musculus |
| Topoisomerase II | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | topoisomerase II isozymes contribute to NO-induced mutagenesis and subsequent cancer development during chronic inflammation. mechanism, overview | Mus musculus |
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Release 2023.1 (January 2023)
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