Application | Comment | Organism |
---|---|---|
medicine | enzyme is the target for antibacterial activity of chuangximycin and chuangximycin lactone | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chuangximycin aldehyde | strong inhibition | Staphylococcus aureus | |
chuangximycin lactone | - |
Staphylococcus aureus | |
chuangximycin nitrile | - |
Staphylococcus aureus | |
chuangxinmycin | CAS: 63339-68-4, natural product, first isolated from Actinoplanes tsinanensis, potent and selective inhibition of the aminoacylation | Staphylococcus aureus | |
indolmycin | - |
Staphylococcus aureus | |
additional information | no inhibition by chuangximycin methyl ester, hydroxamic acid, amide, hydroxymethyl or tetrazole analogue | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Staphylococcus aureus | activity and fidelity are essential for viability | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
purified enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Staphylococcus aureus | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | activity and fidelity are essential for viability | Staphylococcus aureus | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tryptophanyl tRNA synthase | - |
Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Staphylococcus aureus |