Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Thauera aromatica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-fluorobenzoate + CoA | Thauera aromatica | activation of 2-fluorobenzoate by promiscuous AMP-forming benzoate-CoA ligase | AMP + diphosphate + 2-fluorobenzoyl-CoA | - |
? | |
ATP + benzoate + CoA | Thauera aromatica | - |
AMP + diphosphate + benzoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thauera aromatica | Q8GQN9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-fluorobenzoate + CoA | activation of 2-fluorobenzoate by promiscuous AMP-forming benzoate-CoA ligase | Thauera aromatica | AMP + diphosphate + 2-fluorobenzoyl-CoA | - |
? | |
ATP + benzoate + CoA | - |
Thauera aromatica | AMP + diphosphate + benzoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-forming BCL | - |
Thauera aromatica |
AMP-forming benzoate-CoA ligase | - |
Thauera aromatica |
Bcl | - |
Thauera aromatica |
bclA | - |
Thauera aromatica |
benzoate-CoA ligase | - |
Thauera aromatica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Thauera aromatica |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in oxygen-independent defluorination and degradation of 2-fluorobenzoate to CO2 and HF, pathway overview. BCL readily activates 2-fluorobenzoate to 2-fluorobenzoyl-CoA at a rate similar to that of benzoate suggesting that 2-fluorobenzoate metabolism is initiated by CoA thioester formation | Thauera aromatica |