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Literature summary for 6.2.1.76 extracted from

  • Bowman, C.E.; Wolfgang, M.J.
    Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism (2019), Adv. Biol. Regul., 71, 34-40 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.76

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + malonate + CoA Homo sapiens
-
 AMP + diphosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q4G176
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + malonate + CoA
-
 Homo sapiens AMP + diphosphate + malonyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSF3
-
 Homo sapiens
malonyl-CoA synthetase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism a major role for ACSF3 is to provide a metabolic pathway for the clearance of malonate by the generation of malonyl-CoA, which can then be decarboxylated to acetyl-CoA by malonyl-CoA decarboxylase. Additionally, ACSF3-derived malonyl-CoA can be used to malonylate lysine residues on proteins within the matrix of mitochondria, possibly adding another regulatory layer to post-translational control of mitochondrial metabolism Homo sapiens