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Literature summary for 6.2.1.76 extracted from

  • Bowman, C.E.; Rodriguez, S.; Selen Alpergin, E.S.; Acoba, M.G.; Zhao, L.; Hartung, T.; Claypool, S.M.; Watkins, P.A.; Wolfgang, M.J.
    The mammalian malonyl-CoA synthetase ACSF3 is required for mitochondrial protein malonylation and metabolic efficiency (2017), Cell Chem. Biol., 24, 673-684.e4 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + malonate + CoA Homo sapiens
-
 AMP + diphosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q4G176
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + malonate + CoA
-
 Homo sapiens AMP + diphosphate + malonyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSF3
-
 Homo sapiens
malonyl-CoA synthetase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of ACSF3 perturbs mitochondrial metabolism. Impaired mitochondrial malonate metabolism affects cellular energy status and impairs de novo lipogenesis Homo sapiens
physiological function essential role for the enzyme (ACSF3) in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism. ACSF3 is required for the metabolism and therefore detoxification of malonate, ACSF3-derived malonyl-CoA is specifically required for lysine malonylation of mitochondrial proteins Homo sapiens