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Literature summary for 6.3.4.7 extracted from
- Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis (1968), J. Biol. Chem., 243, 5695-5701.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ribose 5-phosphate | inhibition above 0.0125 M | Gallus gallus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.8 | - |
5-O-phosphono-D-ribofuranose | - |
Gallus gallus | |
| 6.3 | - |
NH4+ | - |
Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ribose 5-phosphate + NH4+ | Gallus gallus | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | ? | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | Pigeon | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | ? | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | Anas platyrhynchos | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anas platyrhynchos | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Pigeon | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Pigeon | - |
| liver | - |
Anas platyrhynchos | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -18°C, stable for several months | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ribose 5-phosphate + Asn | far less effective than NH4+ | Gallus gallus | ADP + phosphate + 5-phosphoribosylamine + Asp | - |
? | |
| ATP + ribose 5-phosphate + Gln | far less effective than NH4+ | Gallus gallus | ADP + phosphate + 5-phosphoribosylamine + Glu | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | - |
Gallus gallus | ADP + phosphate + 5-phosphoribosylamine | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | - |
Pigeon | ADP + phosphate + 5-phosphoribosylamine | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | - |
Anas platyrhynchos | ADP + phosphate + 5-phosphoribosylamine | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | Gallus gallus | ? | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | Pigeon | ? | - |
? | |
| ATP + ribose 5-phosphate + NH4+ | alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine | Anas platyrhynchos | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 80 | - |
5 min, inactivation | Gallus gallus |
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