Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Surf1 | biogenesis of mitochondrial cytochrome c oxidase relies on a large number of assembly factors, among them the transmembrane protein Surf1 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | mutations in various mitochondrial enzymes can result in Leigh syndrome, among them cytochrome c oxidase | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ferrocytochrome c + O2 + H+ | Homo sapiens | - |
ferricytochrome c + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ferrocytochrome c + O2 + H+ | - |
Homo sapiens | ferricytochrome c + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | mitochondrial COX consists of up to 13 subunits | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
COX | - |
Homo sapiens |
cytochrome c oxidase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme a | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Leigh syndrome most frequent trigger is deficiency of cytochrome c oxidase caused by mutations in the SURF1 gene | down |