EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.40 | 2-mercaptoethanol | 46% inhibition at 25 mM | Rattus norvegicus | |
3.1.4.40 | 5,5'-dithiobis(2-nitrobenzoic acid) | 16.3% inhibition at 25 mM | Rattus norvegicus | |
3.1.4.40 | cAMP | 19% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | CDP | 64% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | CMP | 37% inhibition at 0.86 mM, 96% inhibition at 3.8 mM | Rattus norvegicus | |
3.1.4.40 | CTP | 84% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | Cu2+ | 38% reduction of enzyme activity at 10 mM | Rattus norvegicus | |
3.1.4.40 | cysteine | 80% inhibition at 25 mM | Rattus norvegicus | |
3.1.4.40 | cytidine | 6.9% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | diphosphate | 41% inhibition at 0.86 mM, 82% inhibition at 6.5 | Rattus norvegicus | |
3.1.4.40 | dithiothreitol | 84% inhibition by 25 mM reduced dithiothreitol, 0% inhibition by 25 mM oxidized dithiotreitol | Rattus norvegicus | |
3.1.4.40 | EDTA | 50% inhibition at 0.2 mM | Rattus norvegicus | |
3.1.4.40 | GDPglucose | competitive, 83% inhibition | Rattus norvegicus | |
3.1.4.40 | GDPmannose | competitive, 85% inhibition | Rattus norvegicus | |
3.1.4.40 | glutathione | 62% inhibition by 25 mM reduced glutathione, 15% inhibition by 25 mM oxidized glutathione | Rattus norvegicus | |
3.1.4.40 | N-ethylmaleimide | 5.8% inhibition at 25 mM | Rattus norvegicus | |
3.1.4.40 | p-chloromercuribenzoate | 7.2% inhibition at 25 mM | Rattus norvegicus | |
3.1.4.40 | TDPglucose | competitive, 70% inhibition | Rattus norvegicus | |
3.1.4.40 | UDP | 76% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | UDP-N-acetylglucosamine | competitive, 58% inhibition | Rattus norvegicus | |
3.1.4.40 | UDPgalactose | 31% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | UDPgalacturonic acid | competitive, 79% inhibition | Rattus norvegicus | |
3.1.4.40 | UDPglucose | competitive, 70% inhibition | Rattus norvegicus | |
3.1.4.40 | UDPglucuronic acid | competitive, 76% inhibition | Rattus norvegicus | |
3.1.4.40 | UDPmannose | competitive, 61% inhibition | Rattus norvegicus | |
3.1.4.40 | UMP | 26% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | uridine | 7.5% inhibition at 0.86 mM | Rattus norvegicus | |
3.1.4.40 | UTP | 83% inhibition at 0.86 mM | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.4.40 | 0.4 | - |
CMP-N-acylneuraminate | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.40 | microsome | - |
Rattus norvegicus | - |
- |
3.1.4.40 | nucleus | - |
Rattus norvegicus | 5634 | - |
3.1.4.40 | plasma membrane | activity in subfractions | Rattus norvegicus | 5886 | - |
3.1.4.40 | plasma membrane | of liver cells | Rattus norvegicus | 5886 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.40 | Ca2+ | restores 20% of initial enzymatic activity when inhibited by EDTA | Rattus norvegicus | |
3.1.4.40 | Mg2+ | restores 8% of initial enzymatic activity when inhibited by EDTA | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.40 | CMP-N-acylneuraminate + H2O | Rattus norvegicus | - |
? | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.40 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.4.40 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.40 | blood | - |
Rattus norvegicus | - |
3.1.4.40 | bone | - |
Rattus norvegicus | - |
3.1.4.40 | brain | - |
Rattus norvegicus | - |
3.1.4.40 | heart | - |
Rattus norvegicus | - |
3.1.4.40 | intestinal mucosa | - |
Rattus norvegicus | - |
3.1.4.40 | kidney | - |
Rattus norvegicus | - |
3.1.4.40 | liver | - |
Rattus norvegicus | - |
3.1.4.40 | muscle | skeletal | Rattus norvegicus | - |
3.1.4.40 | pancreas | - |
Rattus norvegicus | - |
3.1.4.40 | retina | - |
Rattus norvegicus | - |
3.1.4.40 | spleen | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.1.4.40 | additional information | - |
- |
Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
3.1.4.40 | -20°C, plasma membranes, 1 year, microsomes, 3 months, no loss of activity | Rattus norvegicus |
3.1.4.40 | 0°C, for several days no loss of activity, by the 25th day 42% of initial activity remains | Rattus norvegicus |
3.1.4.40 | repeated freezing and thawing, no influence of enzyme activity | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.40 | CMP-N-acylneuraminate + H2O | - |
Rattus norvegicus | CMP + N-acylneuraminate | - |
ir | |
3.1.4.40 | CMP-N-acylneuraminate + H2O | - |
Rattus norvegicus | ? | - |
ir |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.4.40 | 9 | - |
in Tris-HCl buffer | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.4.40 | 0.2 | - |
EDTA | - |
Rattus norvegicus |