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Literature summary extracted from

  • Silverman, R.B.; Nandi, D.R.
    Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide (1988), Biochem. Biophys. Res. Commun., 155, 1248-1254.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.4 dithiothreitol
-
 Rattus norvegicus
1.17.4.4 dithiothreitol
-
 Bos taurus
1.17.4.4 GSH activation, 6% as effective as DTT Rattus norvegicus
1.17.4.4 GSH activation, 6% as effective as DTT Bos taurus
1.17.4.4 lipoic acid activation, less effective than DTT Rattus norvegicus
1.17.4.4 lipoic acid activation, less effective than DTT Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin
-
 Bos taurus
1.17.4.4 warfarin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome integral membrane protein Rattus norvegicus
-
-
1.17.4.4 microsome integral membrane protein Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol Bos taurus
-
 vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus thioredoxin is the possible physiological electron acceptor vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol Rattus norvegicus Wistar thioredoxin is the possible physiological electron acceptor vitamin K + oxidized dithiothreitol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Bos taurus
-
-
-
1.17.4.4 Rattus norvegicus
-
 Wistar strain
-
1.17.4.4 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Rattus norvegicus
-
1.17.4.4 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Bos taurus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol thioredoxin is the possible physiological electron acceptor Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol thioredoxin is the possible physiological electron acceptor Rattus norvegicus Wistar vitamin K + oxidized dithiothreitol
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.4 reduced thioredoxin likely physiological cofactor, more potent than dithiothreitol Rattus norvegicus
1.17.4.4 reduced thioredoxin likely physiological cofactor, more potent than dithiothreitol Bos taurus