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Literature summary extracted from

  • Cash, C.; Ciesielski, L.; Maitre, M.; Mandel, P.
    Purification and properties of rat brain succinic semialdehyde dehydrogenase (1977), Biochimie, 59, 257-268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 4-hydroxybenzaldehyde
-
 Rattus norvegicus
1.2.1.24 ADP
-
 Rattus norvegicus
1.2.1.24 AMP
-
 Rattus norvegicus
1.2.1.24 ATP
-
 Rattus norvegicus
1.2.1.24 benzaldehyde
-
 Rattus norvegicus
1.2.1.24 Chloral hydrate
-
 Rattus norvegicus
1.2.1.24 iodoacetamide
-
 Rattus norvegicus
1.2.1.24 p-bromobenzaldehyde 1 mM, 38% inhibition Rattus norvegicus
1.2.1.24 p-chlorobenzaldehyde 1 mM, 38% inhibition Rattus norvegicus
1.2.1.24 p-ethoxybenzaldehyde 1 mM, 19% inhibition Rattus norvegicus
1.2.1.24 p-ethylbenzaldehyde 1 mM, 51% inhibition Rattus norvegicus
1.2.1.24 p-fluorobenzaldehyde 1 mM, 19% inhibition Rattus norvegicus
1.2.1.24 p-iodobenzaldehyde 1 mM, 52% inhibition Rattus norvegicus
1.2.1.24 p-isopropylbenzaldehyde 1 mM, 19% inhibition Rattus norvegicus
1.2.1.24 p-Methoxybenzaldehyde 1 mM, 19% inhibition Rattus norvegicus
1.2.1.24 p-methylbenzaldehyde 1 mM, 64% inhibition Rattus norvegicus
1.2.1.24 p-nitrobenzaldehyde 1 mM, 20% inhibition Rattus norvegicus
1.2.1.24 succinate semialdehyde
-
 Rattus norvegicus
1.2.1.24 Valeraldehyde
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 0.02
-
 NAD+
-
 Rattus norvegicus
1.2.1.24 0.1
-
 succinate semialdehyde
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.24 68000
-
 2 * 68000, SDS-PAGE Rattus norvegicus
1.2.1.24 140000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.24
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.24 succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+ compulsory ordered mechanism where NAD+ binds first followed by succinate semialdehyde Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.24 27
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O reverse reaction proceeds at 1/1230 of the rate of the forward eaction Rattus norvegicus succinate + NADH
-
 ir
1.2.1.24 succinate semialdehyde + NADP+ + H2O reaction with NADP+ is 13% of the activity with NAD+ Rattus norvegicus succinate + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.24 dimer 2 * 68000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.24 8.6
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.24 7 10 about 50% of maximal activity at pH 7.0 and at pH 10.0 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 NAD+
-
 Rattus norvegicus