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Literature summary extracted from

  • Lees, T.; Lauffart, B.; McDermott, J.; Gibson, A.; Mantle, D.
    Purification and characterization of tripeptidyl-aminopeptidase from human cerebral cortex (1990), Biochem. Soc. Trans., 18, 667.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.4 Cd2+
-
 Homo sapiens
3.4.11.4 Cu2+
-
 Homo sapiens
3.4.11.4 Hg2+
-
 Homo sapiens
3.4.11.4 N-ethylmaleimide
-
 Homo sapiens
3.4.11.4 p-Hydroxymercuriphenyl sulfonate
-
 Homo sapiens
3.4.11.4 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.4 0.25
-
 Ala-Ala-Phe-7-amido-4-methylcoumarin
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.4 100000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.4 cerebral cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.4 Ala-Ala-Phe-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.4 angiotensin II + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.4 cholecystokinin octapeptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.4 enkephalin + H2O
-
 Homo sapiens ?
-
 ?
3.4.11.4 neurokinin alpha + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.4 7.7
-
 in presence of 2 mM dithiothreitol Homo sapiens