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Literature summary extracted from
- Angiotensinase activity of dipeptidyl aminopeptidase I (cathepsin C) of rat liver (1974), J. Biol. Chem., 249, 234-240.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.1 | 0.31 | - |
alpha-Asp-Arg-2-naphthylamide | - |
Rattus norvegicus |  |
| 3.4.14.1 | 0.34 | - |
Ile5-angiotensin II | - |
Rattus norvegicus | |
| 3.4.14.1 | 0.44 | - |
Asn1-angiotensin II | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.1 | additional information | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.14.1 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.14.1 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.14.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.14.1 | alpha-Asp-Arg-2-naphthylamide + H2O | - |
Rattus norvegicus | alpha-Asp-Arg + 2-naphthylamine | - |
? | |
| 3.4.14.1 | alpha-D-Asp1-angiotensin II + H2O | low reaction rate | Rattus norvegicus | ? | - |
? | |
| 3.4.14.1 | Asn1-angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.14.1 | beta-Asp1-angiotensin II + H2O | low reaction rate | Rattus norvegicus | ? | - |
? | |
| 3.4.14.1 | Ile5-angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.14.1 | additional information | - |
Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.14.1 | 87 | - |
Asn1-angiotensin II | removal of the first dipeptide | Rattus norvegicus | |
| 3.4.14.1 | 87 | - |
Ile5-angiotensin II | removal of the first dipeptide | Rattus norvegicus | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.14.1 | 5 | 6 | Asn1-angiotensin II or Ile5-angiotensin II as substrate | Rattus norvegicus |
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Release 2023.1 (January 2023)
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