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Literature summary extracted from
- Partial purification and characterization of complex I, NADH:ubiquinone reductase, from the inner membrane of beetroot mitochondria (1991), Plant Physiol., 98, 588-594.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | Mersalyl | 0.3 mM, 77% inhibition of NADH-ubiquinone-1 reductase activity, 96% inhibition of NADH-potassium ferricyanide reductase activity | Beta vulgaris |  |
| 7.1.1.2 | NAD+ | 4 mM, 19% inhibition of NADH-ubiquinone-1 reductase activity | Beta vulgaris | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.1.1.2 | 0.019 | - |
NADH | reaction with ubiquinone-1 | Beta vulgaris | |
| 7.1.1.2 | 0.055 | - |
ferricyanide | - |
Beta vulgaris | |
| 7.1.1.2 | 0.143 | - |
ubiquinone-1 | - |
Beta vulgaris | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | mitochondrial membrane | inner membrane | Beta vulgaris | 31966 | - |
| 7.1.1.2 | mitochondrion | inner membrane | Beta vulgaris | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Beta vulgaris | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.1.1.2 | - |
Beta vulgaris |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.2 | 3.4 | - |
- |
Beta vulgaris |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | 2 ferricyanide + NADH | - |
Beta vulgaris | 2 ferrocyanide + NAD+ + H+ | - |
? | |
| 7.1.1.2 | additional information | no transhydrogenase activity with NADPH | Beta vulgaris | ? | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Beta vulgaris | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADPH + H+ + ubiquinone-1 | at a slow rate | Beta vulgaris | NADP+ + ubiquinol-1 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | More | isolated complex contains 14 major polypeptides | Beta vulgaris |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | NADH | - |
Beta vulgaris | |
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Release 2023.1 (January 2023)
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