EC Number | Application | Comment | Organism |
---|---|---|---|
1.8.4.2 | medicine | DsbA protein is a target for treatment of pathogenic bacteria | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.8.4.2 | additional information | DsbA and DsbB insertion mutants are sensitive to dithiothreitol and benzylpenicillin or Cd2+, Hg2+ and Zn2+, pleitropic phenotype | Escherichia coli |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.8.4.2 | membrane | outer cytoplasmic membrane, protein termini localised in the periplasm | Escherichia coli | 16020 | - |
1.8.4.2 | periplasm | DsbA protein soluble, DsbB protein is membrane intrinsic | Escherichia coli | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.8.4.2 | 20000 | - |
DsbB gene product | Escherichia coli |
1.8.4.2 | 21100 | - |
DsbA gene product | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.2 | GSH + protein disulfide | Escherichia coli | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | GSSG + protein-dithiol | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.2 | Dickeya chrysanthemi | - |
DsbA homologous | - |
1.8.4.2 | Dickeya chrysanthemi DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Escherichia coli | - |
in periplasm: DsbA and DsbB enzymes | - |
1.8.4.2 | Escherichia coli | - |
different forms of protein thiol:disulfide oxidoreductases with either oxidizing, gene DsbA, reducing, gene DsbB, or isomerising, gene DsbC and DsbD, activity exist in Escherichia coli | - |
1.8.4.2 | Haemophilus influenzae | - |
DsbA homologous | - |
1.8.4.2 | Haemophilus influenzae DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Klebsiella sp. | - |
DsbA homologous | - |
1.8.4.2 | Klebsiella sp. DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Legionella pneumophila | P50024 | DsbA homologous | - |
1.8.4.2 | Legionella pneumophila DsbA homologous | P50024 | DsbA homologous | - |
1.8.4.2 | Lelliottia amnigena | Q9XDP0 | DsbA homologous | - |
1.8.4.2 | Lelliottia amnigena DsbA homologous | Q9XDP0 | DsbA homologous | - |
1.8.4.2 | Pectobacterium carotovorum | - |
DsbA homologous | - |
1.8.4.2 | Pectobacterium carotovorum DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Pseudomonas aeruginosa | P0C2B2 | DsbA homologous | - |
1.8.4.2 | Pseudomonas aeruginosa DsbA homologous | P0C2B2 | DsbA homologous | - |
1.8.4.2 | Pseudomonas syringae | O52376 | DsbA homologous | - |
1.8.4.2 | Pseudomonas syringae DsbA homologous | O52376 | DsbA homologous | - |
1.8.4.2 | Salmonella enterica subsp. enterica serovar Enteritidis | - |
DsbA homologous | - |
1.8.4.2 | Salmonella enterica subsp. enterica serovar Enteritidis DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
DsbA homologous | - |
1.8.4.2 | Salmonella enterica subsp. enterica serovar Typhimurium DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Shigella flexneri | - |
DsbA homologous | - |
1.8.4.2 | Shigella flexneri DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Vibrio cholerae serotype O1 | - |
DsbA homologous | - |
1.8.4.2 | Vibrio cholerae serotype O1 DsbA homologous | - |
DsbA homologous | - |
1.8.4.2 | Yersinia pestis | - |
DsbA homologous | - |
1.8.4.2 | Yersinia pestis DsbA homologous | - |
DsbA homologous | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.8.4.2 | 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol | C-X-X-C motif in active site for disulfide bonding, either oxidizing, reducing and isomerising activity | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.2 | GSH + protein disulfide | very rapid disulfide interchange reaction | Escherichia coli | GSSG + protein-dithiol | - |
r | |
1.8.4.2 | GSH + protein disulfide | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | Escherichia coli | GSSG + protein-dithiol | - |
r | |
1.8.4.2 | additional information | DsbB protein re-oxidizes the reduced DsbA protein | Escherichia coli | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.8.4.2 | monomer | 1 * 21100 | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.4.2 | More | DsbA protein family including periplasmic protein disulfide: thiol oxidoreductases with high homology in amino acid sequences | Escherichia coli |