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Literature summary extracted from

  • Beyer, W.; Imlay, J.; Fridovich, I.
    SODs: varieties and distributions. X-ray crystallography of Mn-SODs and Fe-SODs (1991), Prog. Nucleic Acid Res. Mol. Biol., 40, 221-253.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.15.1.1 additional information naturally occuring hybrids between Fe-SOD and Mn-SOD, altered metal content Escherichia coli
1.15.1.1 additional information naturally occuring exchange of Arg-189 for Lys in the active site of Mn-SOD, sensitivity to lysine-modifying agents Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 H2O2 Cu,Zn-SOD Bacteroides fragilis
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Bacteroides thetaiotaomicron
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Caulobacter vibrioides
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Escherichia coli
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Geobacillus stearothermophilus
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Ginkgo biloba
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Gordonia bronchialis
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Halobacterium salinarum
1.15.1.1 H2O2 Cu,Zn-SOD Homo sapiens
1.15.1.1 H2O2 Cu,Zn-SOD Leptolyngbya boryana
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Methanobacterium bryantii
1.15.1.1 H2O2 Cu,Zn-SOD Mus musculus
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Mycolicibacterium phlei
1.15.1.1 H2O2 Cu,Zn-SOD Nocardia asteroides
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Paracoccus denitrificans
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Photobacterium leiognathi
1.15.1.1 H2O2 Cu,Zn-SOD Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 H2O2 Cu,Zn-SOD Pseudomonas putida
1.15.1.1 H2O2 Cu,Zn-SOD Rattus norvegicus
1.15.1.1 H2O2 Cu,Zn-SOD Saccharomyces cerevisiae
1.15.1.1 H2O2 Cu,Zn-SOD Streptococcus mutans
1.15.1.1 H2O2 Cu,Zn-SOD Synechococcus elongatus PCC 7942 = FACHB-805
1.15.1.1 H2O2 Cu,Zn-SOD; no inhibition: Mn-SOD Thermoplasma acidophilum
1.15.1.1 H2O2 Cu,Zn-SOD Zea mays
1.15.1.1 N3-
-
 Bacteroides fragilis
1.15.1.1 N3-
-
 Bacteroides thetaiotaomicron
1.15.1.1 N3-
-
 Caulobacter vibrioides
1.15.1.1 N3-
-
 Escherichia coli
1.15.1.1 N3-
-
 Ginkgo biloba
1.15.1.1 N3-
-
 Gordonia bronchialis
1.15.1.1 N3-
-
 Halobacterium salinarum
1.15.1.1 N3-
-
 Homo sapiens
1.15.1.1 N3-
-
 Mycolicibacterium phlei
1.15.1.1 N3-
-
 Nocardia asteroides
1.15.1.1 N3-
-
 Paracoccus denitrificans
1.15.1.1 N3-
-
 Photobacterium leiognathi
1.15.1.1 N3-
-
 Pseudomonas putida
1.15.1.1 N3-
-
 Thermoplasma acidophilum
1.15.1.1 N3-
-
 Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 cytoplasm
-
 Synechococcus elongatus PCC 7942 = FACHB-805 5737
-
1.15.1.1 cytoplasm
-
 Paracoccus denitrificans 5737
-
1.15.1.1 cytoplasm
-
 Mus musculus 5737
-
1.15.1.1 cytoplasm
-
 Escherichia coli 5737
-
1.15.1.1 cytoplasm
-
 Homo sapiens 5737
-
1.15.1.1 cytoplasm
-
 Rattus norvegicus 5737
-
1.15.1.1 cytoplasm
-
 Saccharomyces cerevisiae 5737
-
1.15.1.1 cytoplasm
-
 Geobacillus stearothermophilus 5737
-
1.15.1.1 cytoplasm
-
 Zea mays 5737
-
1.15.1.1 cytoplasm
-
 Photobacterium leiognathi 5737
-
1.15.1.1 cytoplasm
-
 Pseudomonas putida 5737
-
1.15.1.1 cytoplasm
-
 Halobacterium salinarum 5737
-
1.15.1.1 cytoplasm
-
 Thermoplasma acidophilum 5737
-
1.15.1.1 cytoplasm
-
 Mycolicibacterium phlei 5737
-
1.15.1.1 cytoplasm
-
 Propionibacterium freudenreichii subsp. shermanii 5737
-
1.15.1.1 cytoplasm
-
 Bacteroides fragilis 5737
-
1.15.1.1 cytoplasm
-
 Nocardia asteroides 5737
-
1.15.1.1 cytoplasm
-
 Caulobacter vibrioides 5737
-
1.15.1.1 cytoplasm
-
 Methanobacterium bryantii 5737
-
1.15.1.1 cytoplasm
-
 Streptococcus mutans 5737
-
1.15.1.1 cytoplasm
-
 Bacteroides thetaiotaomicron 5737
-
1.15.1.1 cytoplasm
-
 Leptolyngbya boryana 5737
-
1.15.1.1 cytoplasm
-
 Ginkgo biloba 5737
-
1.15.1.1 cytoplasm
-
 Gordonia bronchialis 5737
-
1.15.1.1 extracellular
-
 Homo sapiens
-
-
1.15.1.1 extracellular
-
 Saccharomyces cerevisiae
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Escherichia coli
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Photobacterium leiognathi
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Halobacterium salinarum
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Thermoplasma acidophilum
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Mycolicibacterium phlei
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Caulobacter vibrioides
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Methanobacterium bryantii
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Bacteroides thetaiotaomicron
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Ginkgo biloba
-
-
1.15.1.1 extracellular Cu,Zn-SOD in mammalian extracellular fluids Gordonia bronchialis
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+
-
 Paracoccus denitrificans
1.15.1.1 Cu2+
-
 Escherichia coli
1.15.1.1 Cu2+
-
 Homo sapiens
1.15.1.1 Cu2+
-
 Rattus norvegicus
1.15.1.1 Cu2+
-
 Saccharomyces cerevisiae
1.15.1.1 Cu2+
-
 Geobacillus stearothermophilus
1.15.1.1 Cu2+
-
 Zea mays
1.15.1.1 Cu2+
-
 Photobacterium leiognathi
1.15.1.1 Cu2+
-
 Halobacterium salinarum
1.15.1.1 Cu2+
-
 Thermoplasma acidophilum
1.15.1.1 Cu2+
-
 Mycolicibacterium phlei
1.15.1.1 Cu2+
-
 Caulobacter vibrioides
1.15.1.1 Cu2+
-
 Methanobacterium bryantii
1.15.1.1 Cu2+
-
 Bacteroides thetaiotaomicron
1.15.1.1 Cu2+
-
 Ginkgo biloba
1.15.1.1 Cu2+
-
 Gordonia bronchialis
1.15.1.1 Iron
-
 Paracoccus denitrificans
1.15.1.1 Iron
-
 Photobacterium leiognathi
1.15.1.1 Iron
-
 Caulobacter vibrioides
1.15.1.1 Iron
-
 Methanobacterium bryantii
1.15.1.1 Iron 0.9 mol per mol of enzyme Gordonia bronchialis
1.15.1.1 Iron 1.8-1.9 mol (gatoms) per mol of enzyme Escherichia coli
1.15.1.1 Iron 1.8-1.9 mol (gatoms) per mol of enzyme Bacteroides fragilis
1.15.1.1 Iron 2.0 mol per mol of enzyme Thermoplasma acidophilum
1.15.1.1 Iron 2.0 mol per mol of enzyme Nocardia asteroides
1.15.1.1 Iron 2.0 mol per mol of enzyme Leptolyngbya boryana
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Pseudomonas putida
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Mycolicibacterium phlei
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Nocardia asteroides
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Bacteroides thetaiotaomicron
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Leptolyngbya boryana
1.15.1.1 Iron 1.0-1.45 mol per mol of enzyme Ginkgo biloba
1.15.1.1 Mn2+
-
 Paracoccus denitrificans
1.15.1.1 Mn2+
-
 Thermus thermophilus
1.15.1.1 Mn2+
-
 Homo sapiens
1.15.1.1 Mn2+
-
 Saccharomyces cerevisiae
1.15.1.1 Mn2+
-
 Geobacillus stearothermophilus
1.15.1.1 Mn2+
-
 Photobacterium leiognathi
1.15.1.1 Mn2+
-
 Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 Mn2+
-
 Caulobacter vibrioides
1.15.1.1 Mn2+
-
 Methanobacterium bryantii
1.15.1.1 Mn2+
-
 Streptococcus mutans
1.15.1.1 Mn2+ 2.2 mol per mol of enzyme Gordonia bronchialis
1.15.1.1 Mn2+ 1.5 mol per mol of enzyme Halobacterium salinarum
1.15.1.1 Mn2+ 1.7 mol per mol of enzyme Mycolicibacterium phlei
1.15.1.1 Mn2+ 1.1 mol per mol of enzyme Bacteroides fragilis
1.15.1.1 Mn2+ 1.2-1.8 mol per mol of Mn-SOD Escherichia coli
1.15.1.1 Mn2+ 1.2-1.8 mol per mol of Mn-SOD Rattus norvegicus
1.15.1.1 Mn2+ 0.22 mol per mol of enzyme Ginkgo biloba
1.15.1.1 Mn2+ 0.05 mol per mol of enzyme Bacteroides thetaiotaomicron
1.15.1.1 Mn2+ 1.22 mol per mol of enzyme Nocardia asteroides
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Paracoccus denitrificans
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Escherichia coli
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Geobacillus stearothermophilus
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Photobacterium leiognathi
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Halobacterium salinarum
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Thermoplasma acidophilum
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Mycolicibacterium phlei
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Caulobacter vibrioides
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Methanobacterium bryantii
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Bacteroides thetaiotaomicron
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Ginkgo biloba
1.15.1.1 additional information enzyme from eukaryotes contains both copper and zinc, enzymes from most prokaryotes contain manganese or iron Gordonia bronchialis
1.15.1.1 additional information overview: metal content Paracoccus denitrificans
1.15.1.1 additional information overview: metal content Escherichia coli
1.15.1.1 additional information overview: metal content Geobacillus stearothermophilus
1.15.1.1 additional information overview: metal content Photobacterium leiognathi
1.15.1.1 additional information overview: metal content Halobacterium salinarum
1.15.1.1 additional information overview: metal content Thermoplasma acidophilum
1.15.1.1 additional information overview: metal content Mycolicibacterium phlei
1.15.1.1 additional information overview: metal content Caulobacter vibrioides
1.15.1.1 additional information overview: metal content Methanobacterium bryantii
1.15.1.1 additional information overview: metal content Bacteroides thetaiotaomicron
1.15.1.1 additional information overview: metal content Ginkgo biloba
1.15.1.1 additional information overview: metal content Gordonia bronchialis
1.15.1.1 Zn2+
-
 Paracoccus denitrificans
1.15.1.1 Zn2+
-
 Escherichia coli
1.15.1.1 Zn2+
-
 Homo sapiens
1.15.1.1 Zn2+
-
 Rattus norvegicus
1.15.1.1 Zn2+
-
 Geobacillus stearothermophilus
1.15.1.1 Zn2+
-
 Zea mays
1.15.1.1 Zn2+
-
 Photobacterium leiognathi
1.15.1.1 Zn2+
-
 Caulobacter vibrioides
1.15.1.1 Zn2+ 2.2 mol per mol of enzyme Ginkgo biloba
1.15.1.1 Zn2+ 1.5 mol per mol of enzyme Halobacterium salinarum
1.15.1.1 Zn2+ 0.6-0.7 mol per mol of enzyme Mycolicibacterium phlei
1.15.1.1 Zn2+ 0.6-0.7 mol per mol of enzyme Bacteroides thetaiotaomicron
1.15.1.1 Zn2+ 1.2 mol per mol of enzyme Nocardia asteroides
1.15.1.1 Zn2+ 0.2 mol of Cu per mol of enzyme Bacteroides fragilis
1.15.1.1 Zn2+ 0.2 mol of Cu per mol of enzyme Leptolyngbya boryana
1.15.1.1 Zn2+ 1.0 gatom per mol of enzyme Thermoplasma acidophilum
1.15.1.1 Zn2+ 1.8 mol of Zn per mol of enzyme Saccharomyces cerevisiae
1.15.1.1 Zn2+ 1.8 mol of Zn per mol of enzyme Methanobacterium bryantii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.15.1.1 20000
-
 2 * 20000, SDS-PAGE Bacteroides fragilis
1.15.1.1 21000
-
 2 * 21000, Fe-SOD Escherichia coli
1.15.1.1 22900
-
 2 * 22900, Mn-SOD Escherichia coli
1.15.1.1 32000
-
 x * 32000 Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 38500
-
-
 Halobacterium salinarum
1.15.1.1 42000 43000
-
 Bacteroides fragilis
1.15.1.1 42000 43000
-
 Leptolyngbya boryana
1.15.1.1 46000
-
-
 Bacteroides thetaiotaomicron
1.15.1.1 47000
-
-
 Ginkgo biloba
1.15.1.1 80000
-
-
 Mycolicibacterium phlei
1.15.1.1 80000
-
-
 Gordonia bronchialis
1.15.1.1 82000
-
-
 Thermoplasma acidophilum
1.15.1.1 91000
-
-
 Methanobacterium bryantii
1.15.1.1 100000
-
-
 Nocardia asteroides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2- + H+ Synechococcus elongatus PCC 7942 = FACHB-805
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Paracoccus denitrificans
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Mus musculus
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Escherichia coli
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Saccharomyces cerevisiae
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Geobacillus stearothermophilus
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Photobacterium leiognathi
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Halobacterium salinarum
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Thermoplasma acidophilum
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Mycolicibacterium phlei
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Propionibacterium freudenreichii subsp. shermanii
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Bacteroides fragilis
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Caulobacter vibrioides
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Methanobacterium bryantii
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Bacteroides thetaiotaomicron
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Ginkgo biloba
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Gordonia bronchialis
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Photobacterium leiognathi CuZn-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Caulobacter vibrioides CuZn-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Escherichia coli Mn-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Escherichia coli Fe-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Paracoccus denitrificans CuZn-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Geobacillus stearothermophilus Mn-SOD
-
 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+ Thermoplasma acidophilum Fe-SOD
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Bacteroides fragilis
-
-
-
1.15.1.1 Bacteroides fragilis
-
 Fe-SOD, when grown anaerobically
-
1.15.1.1 Bacteroides thetaiotaomicron
-
-
-
1.15.1.1 Caulobacter vibrioides
-
 Cu,Zn-SOD
-
1.15.1.1 Caulobacter vibrioides CuZn-SOD
-
 Cu,Zn-SOD
-
1.15.1.1 Escherichia coli
-
 Mn-SOD
-
1.15.1.1 Escherichia coli
-
 Fe-SOD
-
1.15.1.1 Escherichia coli Fe-SOD
-
 Fe-SOD
-
1.15.1.1 Escherichia coli Mn-SOD
-
 Mn-SOD
-
1.15.1.1 Geobacillus stearothermophilus
-
 Mn-SOD
-
1.15.1.1 Geobacillus stearothermophilus Mn-SOD
-
 Mn-SOD
-
1.15.1.1 Ginkgo biloba
-
-
-
1.15.1.1 Gordonia bronchialis
-
-
-
1.15.1.1 Halobacterium salinarum
-
-
-
1.15.1.1 Homo sapiens
-
-
-
1.15.1.1 Leptolyngbya boryana
-
-
-
1.15.1.1 Methanobacterium bryantii
-
-
-
1.15.1.1 Mus musculus
-
-
-
1.15.1.1 Mycolicibacterium phlei
-
-
-
1.15.1.1 Nocardia asteroides
-
-
-
1.15.1.1 Paracoccus denitrificans
-
 Cu,Zn-SOD
-
1.15.1.1 Paracoccus denitrificans CuZn-SOD
-
 Cu,Zn-SOD
-
1.15.1.1 Photobacterium leiognathi
-
 Cu,Zn-SOD
-
1.15.1.1 Photobacterium leiognathi CuZn-SOD
-
 Cu,Zn-SOD
-
1.15.1.1 Propionibacterium freudenreichii subsp. shermanii
-
 structural intermediate between Mn-SOD and Fe-SOD
-
1.15.1.1 Pseudomonas putida
-
 Fe-SOD
-
1.15.1.1 Pseudomonas putida Fe-SOD
-
 Fe-SOD
-
1.15.1.1 Rattus norvegicus
-
-
-
1.15.1.1 Saccharomyces cerevisiae
-
-
-
1.15.1.1 Streptococcus mutans
-
 Mn-SOD and Fe-SOD
-
1.15.1.1 Synechococcus elongatus PCC 7942 = FACHB-805
-
-
-
1.15.1.1 Thermoplasma acidophilum
-
 Fe-SOD
-
1.15.1.1 Thermoplasma acidophilum Fe-SOD
-
 Fe-SOD
-
1.15.1.1 Thermus thermophilus
-
 Mn-SOD
-
1.15.1.1 Thermus thermophilus Mn-SOD
-
 Mn-SOD
-
1.15.1.1 Zea mays
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.15.1.1 glycoprotein
-
 Homo sapiens
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Escherichia coli
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Photobacterium leiognathi
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Halobacterium salinarum
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Thermoplasma acidophilum
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Mycolicibacterium phlei
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Caulobacter vibrioides
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Methanobacterium bryantii
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Bacteroides thetaiotaomicron
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Ginkgo biloba
1.15.1.1 glycoprotein Cu,Zn-SOD in mammalian extracellular fluids Gordonia bronchialis

Reaction

EC Number Reaction Comment Organism Reaction ID
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Paracoccus denitrificans
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Escherichia coli
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Geobacillus stearothermophilus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Photobacterium leiognathi
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Halobacterium salinarum
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Thermoplasma acidophilum
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Mycolicibacterium phlei
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Caulobacter vibrioides
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Methanobacterium bryantii
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Bacteroides thetaiotaomicron
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Ginkgo biloba
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 mechanism Gordonia bronchialis
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Synechococcus elongatus PCC 7942 = FACHB-805
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Mus musculus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Thermus thermophilus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Escherichia coli
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Homo sapiens
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Rattus norvegicus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Saccharomyces cerevisiae
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Geobacillus stearothermophilus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Zea mays
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Photobacterium leiognathi
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Pseudomonas putida
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 amino acid sequence alignment and comparison Halobacterium salinarum
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 active site, manganese-binding site and contact site between monomers Thermus thermophilus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 active site, manganese-binding site and contact site between monomers Escherichia coli
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 active site, manganese-binding site and contact site between monomers Geobacillus stearothermophilus
a
1.15.1.1 2 superoxide + 2 H+ = O2 + H2O2 active site is not conserved, differing from others of Mn-SOD and Fe-SOD Halobacterium salinarum
a

Renatured (Commentary)

EC Number Renatured (Comment) Organism
1.15.1.1 reconstitution of active enzyme after withdrawal of metal either with the native metal or with cadmium, chromium or iron Pseudomonas putida

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.15.1.1 additional information
-
-
 Paracoccus denitrificans
1.15.1.1 additional information
-
-
 Thermus thermophilus
1.15.1.1 additional information
-
-
 Escherichia coli
1.15.1.1 additional information
-
-
 Homo sapiens
1.15.1.1 additional information
-
-
 Rattus norvegicus
1.15.1.1 additional information
-
-
 Saccharomyces cerevisiae
1.15.1.1 additional information
-
-
 Zea mays
1.15.1.1 additional information
-
-
 Photobacterium leiognathi
1.15.1.1 additional information
-
-
 Pseudomonas putida
1.15.1.1 additional information
-
-
 Thermoplasma acidophilum
1.15.1.1 additional information
-
-
 Mycolicibacterium phlei
1.15.1.1 additional information
-
-
 Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 additional information
-
-
 Bacteroides fragilis
1.15.1.1 additional information
-
-
 Nocardia asteroides
1.15.1.1 additional information
-
-
 Caulobacter vibrioides
1.15.1.1 additional information
-
-
 Methanobacterium bryantii
1.15.1.1 additional information
-
-
 Streptococcus mutans
1.15.1.1 additional information
-
-
 Bacteroides thetaiotaomicron
1.15.1.1 additional information
-
-
 Leptolyngbya boryana
1.15.1.1 additional information
-
-
 Ginkgo biloba

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2- + H+
-
 Synechococcus elongatus PCC 7942 = FACHB-805 O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Paracoccus denitrificans O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Mus musculus O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Thermus thermophilus O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Escherichia coli O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Saccharomyces cerevisiae O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Geobacillus stearothermophilus O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Photobacterium leiognathi O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Pseudomonas putida O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Halobacterium salinarum O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Thermoplasma acidophilum O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Mycolicibacterium phlei O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Propionibacterium freudenreichii subsp. shermanii O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Bacteroides fragilis O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Caulobacter vibrioides O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Methanobacterium bryantii O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Bacteroides thetaiotaomicron O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Ginkgo biloba O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Gordonia bronchialis O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Synechococcus elongatus PCC 7942 = FACHB-805 O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Paracoccus denitrificans O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Mus musculus O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Escherichia coli O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Homo sapiens O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Rattus norvegicus O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Saccharomyces cerevisiae O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Geobacillus stearothermophilus O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Zea mays O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Photobacterium leiognathi O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Halobacterium salinarum O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Thermoplasma acidophilum O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Mycolicibacterium phlei O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Propionibacterium freudenreichii subsp. shermanii O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Bacteroides fragilis O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Nocardia asteroides O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Caulobacter vibrioides O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Methanobacterium bryantii O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Streptococcus mutans O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Bacteroides thetaiotaomicron O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Leptolyngbya boryana O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Ginkgo biloba O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Gordonia bronchialis O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Thermus thermophilus Mn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Photobacterium leiognathi CuZn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Photobacterium leiognathi CuZn-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Caulobacter vibrioides CuZn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Caulobacter vibrioides CuZn-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Pseudomonas putida Fe-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Escherichia coli Mn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Escherichia coli Mn-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Escherichia coli Fe-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Escherichia coli Fe-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Paracoccus denitrificans CuZn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Paracoccus denitrificans CuZn-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Geobacillus stearothermophilus Mn-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Geobacillus stearothermophilus Mn-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?
1.15.1.1 O2- + H+
-
 Thermoplasma acidophilum Fe-SOD O2 + H2O2
-
 ?
1.15.1.1 O2- + H+
-
 Thermoplasma acidophilum Fe-SOD O2 + H2O2 Fe-SODs are inhibited by H2O2, but Mn-SODs are not ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 ?
-
 Homo sapiens
1.15.1.1 ?
-
 Rattus norvegicus
1.15.1.1 ? x * 32000 Propionibacterium freudenreichii subsp. shermanii
1.15.1.1 dimer
-
 Paracoccus denitrificans
1.15.1.1 dimer
-
 Thermus thermophilus
1.15.1.1 dimer
-
 Rattus norvegicus
1.15.1.1 dimer
-
 Saccharomyces cerevisiae
1.15.1.1 dimer
-
 Geobacillus stearothermophilus
1.15.1.1 dimer
-
 Zea mays
1.15.1.1 dimer
-
 Photobacterium leiognathi
1.15.1.1 dimer
-
 Pseudomonas putida
1.15.1.1 dimer
-
 Halobacterium salinarum
1.15.1.1 dimer
-
 Nocardia asteroides
1.15.1.1 dimer
-
 Streptococcus mutans
1.15.1.1 dimer
-
 Bacteroides thetaiotaomicron
1.15.1.1 dimer
-
 Leptolyngbya boryana
1.15.1.1 dimer
-
 Ginkgo biloba
1.15.1.1 dimer 2 * 20000, SDS-PAGE Bacteroides fragilis
1.15.1.1 dimer 2 * 22900, Mn-SOD Escherichia coli
1.15.1.1 dimer 2 * 21000, Fe-SOD Escherichia coli
1.15.1.1 More three-dimensional structure of Mn-SOD monomer Geobacillus stearothermophilus
1.15.1.1 tetramer
-
 Mus musculus
1.15.1.1 tetramer
-
 Thermus thermophilus
1.15.1.1 tetramer
-
 Homo sapiens
1.15.1.1 tetramer
-
 Rattus norvegicus
1.15.1.1 tetramer
-
 Saccharomyces cerevisiae
1.15.1.1 tetramer
-
 Zea mays
1.15.1.1 tetramer
-
 Thermoplasma acidophilum
1.15.1.1 tetramer
-
 Mycolicibacterium phlei
1.15.1.1 tetramer
-
 Nocardia asteroides
1.15.1.1 tetramer
-
 Methanobacterium bryantii
1.15.1.1 tetramer
-
 Gordonia bronchialis

Cofactor

EC Number Cofactor Comment Organism Structure
1.15.1.1 additional information a liganding water molecule is evident Thermus thermophilus
1.15.1.1 additional information a liganding water molecule is evident Escherichia coli