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Literature summary extracted from

  • Ogawa, H.; Gomi, T.; Fujioka, M.
    Serine hydroxymethyltransferase and threonine aldolase: are they identical? (2000), Int. J. Biochem. Cell Biol., 32, 289-301.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.1 medicine enzyme is a potential target for cancer chemotherapy Escherichia coli
2.1.2.1 medicine enzyme is a potential target for cancer chemotherapy Homo sapiens
2.1.2.1 medicine enzyme is a potential target for cancer chemotherapy Oryctolagus cuniculus
2.1.2.1 medicine enzyme is a potential target for cancer chemotherapy Ovis aries
2.1.2.1 medicine enzyme is a potential target for cancer chemotherapy Pisum sativum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.1
-
 Escherichia coli
2.1.2.1
-
 Homo sapiens
2.1.2.1
-
 Neurospora crassa
2.1.2.1
-
 Vigna radiata

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.2.1
-
 Homo sapiens
2.1.2.1
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 4-chloro-L-threonine
-
 Cricetulus griseus
2.1.2.1 4-chloro-L-threonine
-
 Escherichia coli
2.1.2.1 4-chloro-L-threonine
-
 Homo sapiens
2.1.2.1 4-chloro-L-threonine
-
 Neurospora crassa
2.1.2.1 4-chloro-L-threonine
-
 Oryctolagus cuniculus
2.1.2.1 4-chloro-L-threonine
-
 Ovis aries
2.1.2.1 4-chloro-L-threonine
-
 Pisum sativum
2.1.2.1 4-chloro-L-threonine
-
 Rattus norvegicus
2.1.2.1 4-chloro-L-threonine
-
 Vigna radiata

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.1 additional information
-
 review Escherichia coli
2.1.2.1 additional information
-
 review Homo sapiens
2.1.2.1 additional information
-
 review Rattus norvegicus
2.1.2.1 additional information
-
 review Oryctolagus cuniculus
2.1.2.1 additional information
-
 review Ovis aries
2.1.2.1 additional information
-
 review Pisum sativum
2.1.2.1 additional information
-
 review Vigna radiata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate Cricetulus griseus
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Oryctolagus cuniculus
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Neurospora crassa
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Ovis aries
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Pisum sativum
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Vigna radiata
-
 glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Escherichia coli major pathway for production of C1-units of 5,10-methylenetetrahydrofolate glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Homo sapiens major pathway for production of C1-units of 5,10-methylenetetrahydrofolate glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate Rattus norvegicus major pathway for production of C1-units of 5,10-methylenetetrahydrofolate glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Cricetulus griseus
-
-
-
2.1.2.1 Escherichia coli
-
-
-
2.1.2.1 Homo sapiens
-
-
-
2.1.2.1 Neurospora crassa
-
-
-
2.1.2.1 Oryctolagus cuniculus
-
-
-
2.1.2.1 Ovis aries
-
-
-
2.1.2.1 Pisum sativum
-
-
-
2.1.2.1 Rattus norvegicus
-
-
-
2.1.2.1 Vigna radiata
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Cricetulus griseus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Escherichia coli
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Homo sapiens
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Oryctolagus cuniculus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Neurospora crassa
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Ovis aries
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Cricetulus griseus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Escherichia coli
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Homo sapiens
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Rattus norvegicus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Oryctolagus cuniculus
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Neurospora crassa
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Ovis aries
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Pisum sativum
a
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct Vigna radiata
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.1 additional information
-
 review Escherichia coli
2.1.2.1 additional information
-
 review Homo sapiens
2.1.2.1 additional information
-
 review Rattus norvegicus
2.1.2.1 additional information
-
 review Oryctolagus cuniculus
2.1.2.1 additional information
-
 review Ovis aries
2.1.2.1 additional information
-
 review Pisum sativum
2.1.2.1 additional information
-
 review Vigna radiata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Cricetulus griseus D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Escherichia coli D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Homo sapiens D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Oryctolagus cuniculus D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Neurospora crassa D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Ovis aries D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 alpha-methylserine + tetrahydrofolate
-
 Pisum sativum D-alanine + 5,10-methylenetetrahydrofolate
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Cricetulus griseus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Escherichia coli glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Rattus norvegicus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Oryctolagus cuniculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Neurospora crassa glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Ovis aries glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Pisum sativum glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate
-
 Vigna radiata glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate major pathway for production of C1-units of 5,10-methylenetetrahydrofolate Escherichia coli glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate major pathway for production of C1-units of 5,10-methylenetetrahydrofolate Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate major pathway for production of C1-units of 5,10-methylenetetrahydrofolate Rattus norvegicus glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Cricetulus griseus ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Escherichia coli ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Homo sapiens ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Rattus norvegicus ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Oryctolagus cuniculus ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Neurospora crassa ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Ovis aries ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Pisum sativum ?
-
 ?
2.1.2.1 additional information review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources Vigna radiata ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Cricetulus griseus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Escherichia coli ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Rattus norvegicus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Oryctolagus cuniculus ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Neurospora crassa ?
-
 ?
2.1.2.1 additional information enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate Ovis aries ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.2.1 homotetramer
-
 Cricetulus griseus
2.1.2.1 homotetramer review Escherichia coli
2.1.2.1 homotetramer review Homo sapiens
2.1.2.1 homotetramer review Rattus norvegicus
2.1.2.1 homotetramer review Oryctolagus cuniculus
2.1.2.1 homotetramer review Ovis aries
2.1.2.1 homotetramer review Pisum sativum
2.1.2.1 homotetramer review Vigna radiata

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate
-
 Cricetulus griseus
2.1.2.1 pyridoxal 5'-phosphate
-
 Escherichia coli
2.1.2.1 pyridoxal 5'-phosphate
-
 Homo sapiens
2.1.2.1 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.1.2.1 pyridoxal 5'-phosphate
-
 Oryctolagus cuniculus
2.1.2.1 pyridoxal 5'-phosphate
-
 Ovis aries
2.1.2.1 pyridoxal 5'-phosphate
-
 Pisum sativum
2.1.2.1 pyridoxal 5'-phosphate
-
 Vigna radiata