EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.34 | 5,5'-dithiobis(2-nitrobenzoate) | 0.1 mM, 60% inhibition | Homo sapiens | |
1.5.1.34 | CoCl2 | 0.01 mM, 30% inhibition | Homo sapiens | |
1.5.1.34 | HgCl2 | 0.0001 mM, 60% inhibition | Homo sapiens | |
1.5.1.34 | iodoacetamide | - |
Homo sapiens | |
1.5.1.34 | additional information | not inhibited by EDTA, o-phenanthroline, and 2,2'-bipyridyl | Homo sapiens | |
1.5.1.34 | N-ethylmaleimide | 1 mM, 76% inhibition | Homo sapiens | |
1.5.1.34 | p-chloromercuribenzoate | 0.01 mM, 70% inhibition | Homo sapiens | |
1.5.1.34 | tetrahydrobiopterin | above 0.05 mM, substrate inhibition | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.34 | 0.017 | - |
tetrahydrobiopterin | - |
Homo sapiens | |
1.5.1.34 | 0.029 | - |
NADH | - |
Homo sapiens | |
1.5.1.34 | 0.036 | - |
2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine | - |
Homo sapiens | |
1.5.1.34 | 0.77 | - |
NADPH | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.34 | 26000 | - |
2 * 26000, SDS-PAGE | Homo sapiens |
1.5.1.34 | 47500 | - |
- |
Homo sapiens |
1.5.1.34 | 50000 | - |
- |
Homo sapiens |
1.5.1.34 | 54000 | - |
gradient PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.34 | quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | Homo sapiens | essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.34 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.34 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.34 | liver | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.34 | 422 | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.34 | 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H | NADH is 20fold more effective than NADPH | Homo sapiens | 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+ | - |
? | |
1.5.1.34 | 6,7-dihydropteridine + NADH | - |
Homo sapiens | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+ | - |
? | |
1.5.1.34 | quinoid dihydrobiopterin + NAD(P)H | NADH is 2.5fold more effective than NADPH | Homo sapiens | tetrahydrobiopterin + NAD(P)+ | - |
? | |
1.5.1.34 | quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan | Homo sapiens | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.34 | dimer | 2 * 26000, SDS-PAGE | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.34 | 37 | - |
- |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.34 | 200 | - |
tetrahydrobiopterin | - |
Homo sapiens | |
1.5.1.34 | 510 | - |
2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.34 | 7.2 | - |
- |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.34 | NADH | utilizes both NADH and NADPH | Homo sapiens | |
1.5.1.34 | NADH | enzyme prefers NADH | Homo sapiens | |
1.5.1.34 | NADPH | utilizes both NADH and NADPH | Homo sapiens | |
1.5.1.34 | NADPH | NADH is preferred | Homo sapiens |