Literature summary extracted from

Reyes, V.M.; Greasley, S.E.; Stura, E.A.; Beardsley, G.P.; Wilson, I.A.
Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli (2000), Acta Crystallogr. Sect. D, 56, 1051-1054.

No PubMed abstract available

Application

EC Number	Application	Comment	Organism
2.1.2.3	medicine	attractive anticancer target	Gallus sp.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
2.1.2.3	ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2°	Gallus sp.
2.1.2.3	crystallized in a binary complex with methotrexate, single crystal at 96 K to 2.3 A resolution, monoclinic crystals, space group P2(1), with unit-cell dimensions a = 65.17, B = 105.93, c= 103.47 A, beta = 108.27 degrees	Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.2.3	10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	Gallus sp.	penultimate and final steps in the de novo purine biosynthesis pathway	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.2.3	Gallus sp.	-	avian	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.1.2.3	recombinant avian ATIC, purified from E. coli expression system	Gallus sp.

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.2.3	10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide	penultimate and final steps in the de novo purine biosynthesis pathway	Gallus sp.	tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide	-	r
2.1.2.3	additional information	in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene	Gallus sp.	?	-	?
2.1.2.3	N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide	-	Gallus sp.	tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.2.3	5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase	-	Gallus sp.
2.1.2.3	ATIC	-	Gallus sp.
2.1.2.3	IMPCH	-	Gallus sp.

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Release 2023.1 (January 2023)