Literature summary extracted from
Tsuboi, S.; Kotani, Y.; Ogawa, K.i.; Hatanaka, T.; Yatsushiro, S.; Otsuka, M.; Moriyama, Y.
An Intramolecular Disulfide Bridge as a Catalytic Switch for Serotonin N-Acetyltransferase (2002), J. Biol. Chem., 277, 44229-44235.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
2.3.1.87 |
C177A |
fully active, not sensitive to oxidation or N-ethylmaleimide |
Rattus norvegicus |
2.3.1.87 |
C61A |
fully active, not sensitive to oxidation or N-ethylmaleimide |
Rattus norvegicus |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.3.1.87 |
glutathione |
reversible, acetyl-CoA protects |
Rattus norvegicus |
|
2.3.1.87 |
N-ethylmaleimide |
irreversible, acetyl-CoA protects |
Rattus norvegicus |
|
2.3.1.87 |
oxygen |
reversible, acetyl-CoA protects |
Rattus norvegicus |
|
KM Value [mM]
EC Number |
KM Value [mM] |
KM Value Maximum [mM] |
Substrate |
Comment |
Organism |
Structure |
---|
2.3.1.87 |
additional information |
- |
additional information |
formation and cleavage of a disulfide bond produce active/inactive states of enzyme |
Rattus norvegicus |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.1.87 |
Rattus norvegicus |
Q64666 |
- |
- |