Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Masurekar, P.S.; Demain, A.L.
    Insensitivity of homocitrate synthase in extracts of Penicillium chrysogenum to feedback inhibition by lysine (1974), Appl. Microbiol., 28, 265-270.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.3.14 ATP required Penicillium chrysogenum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.14 benzylpenicillin 20 mM, partial inhibition is enhanced by lysine Penicillium chrysogenum
2.3.3.14 casein hydrolysate about 50% inhibition Penicillium chrysogenum
2.3.3.14 L-Lys no inhibition Penicillium chrysogenum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.3.14 5.5
-
 2-oxoglutarate
-
 Penicillium chrysogenum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.3.14 Mg2+ required Penicillium chrysogenum

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.14 Penicillium chrysogenum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.14 mycelium
-
 Penicillium chrysogenum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate
-
 Penicillium chrysogenum 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.3.14 6.9
-
-
 Penicillium chrysogenum