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Literature summary extracted from

  • Luengo, J.M.; Revilla, G.; Lopez, M.J.; Villanueva, J.R.; Martin, J.M.
    Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum (1980), J. Bacteriol., 144, 869-876.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.14 L-Lys 50 mM, 48% inhibition. Feed-back inhibition Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate Penicillium chrysogenum first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis 2-hydroxybutane-1,2,4-tricarboxylate + CoA
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Organism

EC Number Organism UniProt Comment Textmining
2.3.3.14 Penicillium chrysogenum
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.14 mycelium
-
 Penicillium chrysogenum
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate
-
 Penicillium chrysogenum 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis Penicillium chrysogenum 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?