Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Park, J.; Leong, M.L.; Buse, P.; Maiyar, A.C.; Firestone, G.L.; Hemmings, B.A.
    Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway (1999), EMBO J., 18, 3024-3033.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 additional information transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 S442X mutation of putative phosphorylation sites at Thr256 and Ser422 inhibited SGK activation Rattus norvegicus
2.7.11.1 T256X mutation of putative phosphorylation sites at Thr256 and Ser422 inhibited SGK activation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 additional information treatment of rat mammary tumor cells with serum causes hyperphosphorylation of endogenous SGK, and a promoted translocation to the nucleus Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 additional information Rattus norvegicus the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element ?
-
 ?
2.7.11.1 additional information Rattus norvegicus enzyme is induced during ovarian cell differentiation ?
-
 ?
2.7.11.1 additional information Rattus norvegicus SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Rattus norvegicus Q06226
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 embryo embryo kidney 293 cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 additional information the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element Rattus norvegicus ?
-
 ?
2.7.11.1 additional information enzyme is induced during ovarian cell differentiation Rattus norvegicus ?
-
 ?
2.7.11.1 additional information SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 serine/threonine-protein kinase Sgk
-
 Rattus norvegicus
2.7.11.1 SGK
-
 Rattus norvegicus