EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.145 | 2'-deoxycytidine | competitive with thymidine | Drosophila melanogaster | |
2.7.1.145 | 2'-deoxyguanosine | - |
Drosophila melanogaster | |
2.7.1.145 | thymidine | competitive with 2'-deoxycytidine | Drosophila melanogaster | |
2.7.1.145 | TTP | feed-back inhibition | Drosophila melanogaster |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.145 | 0.001 | - |
thymidine | pH 8.0, 22°C | Drosophila melanogaster | |
2.7.1.145 | 0.001 | - |
2'-deoxycytidine | pH 8.0, 22°C | Drosophila melanogaster | |
2.7.1.145 | 0.0014 | - |
ATP | pH 8.0, 22°C, reaction with 2'-deoxycytidine | Drosophila melanogaster | |
2.7.1.145 | 0.0022 | - |
ATP | pH 8.0, 22°C, reaction with thymidine | Drosophila melanogaster |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.145 | 29000 | - |
1 * 29000, SDS-PAGE | Drosophila melanogaster |
2.7.1.145 | 30000 | - |
gel filtration | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.145 | Drosophila melanogaster | - |
S-2 | - |
2.7.1.145 | Drosophila melanogaster S-2 | - |
S-2 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.145 | - |
Drosophila melanogaster |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.145 | embryo | - |
Drosophila melanogaster | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.145 | 30 | - |
- |
Drosophila melanogaster |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.145 | 1-beta-D-arabinofuranosylcytosine + ATP | 50% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 1-beta-D-arabinofuranosylcytosine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 1-beta-D-arabinofuranosylthymine + ATP | 15% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 1-beta-D-arabinofuranosylthymine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 2'-deoxyadenosine + ATP | 15% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 2'-deoxyadenosine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 2'-deoxycytidine + ATP | - |
Drosophila melanogaster | 2'-deoxycytidine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 2'-deoxycytidine + ATP | - |
Drosophila melanogaster S-2 | 2'-deoxycytidine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 2'-deoxyguanosine + ATP | 4% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 2'-deoxyguanosine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | 3'-azidothymidine + ATP | 0.3% of the activity with thymidine and 2'-deoxycytidine | Drosophila melanogaster | 3'-azidothymidine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | additional information | no activity with acyclovir | Drosophila melanogaster | ? | - |
? | |
2.7.1.145 | additional information | no activity with TMP | Drosophila melanogaster | ? | - |
? | |
2.7.1.145 | additional information | CTP has the same phosphotransfer capability as ATP | Drosophila melanogaster | ? | - |
? | |
2.7.1.145 | additional information | no activity with acyclovir | Drosophila melanogaster S-2 | ? | - |
? | |
2.7.1.145 | additional information | no activity with TMP | Drosophila melanogaster S-2 | ? | - |
? | |
2.7.1.145 | additional information | CTP has the same phosphotransfer capability as ATP | Drosophila melanogaster S-2 | ? | - |
? | |
2.7.1.145 | thymidine + ATP | - |
Drosophila melanogaster | thymidine 5'-phosphate + ADP | - |
? | |
2.7.1.145 | thymidine + ATP | - |
Drosophila melanogaster S-2 | thymidine 5'-phosphate + ADP | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.145 | monomer | 1 * 29000, SDS-PAGE | Drosophila melanogaster |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.145 | additional information | - |
additional information | - |
Drosophila melanogaster |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.145 | 0.001 | - |
thymidine | pH 8.0, 22°C, competitive with 2'-deoxycytidine | Drosophila melanogaster | |
2.7.1.145 | 0.001 | - |
2'-deoxycytidine | pH 8.0, 22°C, competitive with thymidine | Drosophila melanogaster | |
2.7.1.145 | 0.005 | - |
TTP | pH 8.0, 22°C | Drosophila melanogaster |