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Literature summary extracted from

  • Mudd, S.H.
    The adenosyltransferases (1973), The Enzymes, 3rd. Ed. (Boyer P. D. ed. ), 8, 121-154.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.17 diphosphate
-
Clostridium tetanomorphum
2.5.1.17 EDTA
-
Clostridium tetanomorphum
2.5.1.17 Trimetaphosphate
-
Clostridium tetanomorphum
2.5.1.17 tripolyphosphate
-
Clostridium tetanomorphum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.17 0.01
-
cyanocob(I)alamin
-
Clostridium tetanomorphum
2.5.1.17 0.016
-
ATP
-
Clostridium tetanomorphum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.17 Co2+ activation, less effective than Mn2+ Clostridium tetanomorphum
2.5.1.17 K+
-
Propionibacterium freudenreichii subsp. shermanii
2.5.1.17 K+
-
Clostridium tetanomorphum
2.5.1.17 Mg2+
-
Propionibacterium freudenreichii subsp. shermanii
2.5.1.17 Mg2+ activation, less effective than Mn2+ Clostridium tetanomorphum
2.5.1.17 Mn2+
-
Clostridium tetanomorphum
2.5.1.17 additional information no activation by Ca2+ or Cd2+ Propionibacterium freudenreichii subsp. shermanii
2.5.1.17 additional information no activation by Ca2+ or Cd2+ Clostridium tetanomorphum
2.5.1.17 Zn2+
-
Propionibacterium freudenreichii subsp. shermanii
2.5.1.17 Zn2+ activation, less effective than Mn2+ Clostridium tetanomorphum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.17 ATP + cob(I)alamin Propionibacterium freudenreichii subsp. shermanii
-
triphosphate + coenzyme B12
-
?
2.5.1.17 ATP + cob(I)alamin Clostridium tetanomorphum
-
triphosphate + coenzyme B12
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.17 Clostridium tetanomorphum
-
-
-
2.5.1.17 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.17 protamine sulfate, heat treatment and chromatography on Sephadex G-25 and DEAE-cellulose Clostridium tetanomorphum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.17 ATP + cob(I)alamin
-
Propionibacterium freudenreichii subsp. shermanii triphosphate + coenzyme B12
-
?
2.5.1.17 ATP + cob(I)alamin
-
Clostridium tetanomorphum triphosphate + coenzyme B12
-
?
2.5.1.17 ATP + cob(I)alamin
-
Propionibacterium freudenreichii subsp. shermanii triphosphate + coenzyme B12 adenosylcobalamin, B12-coenzyme or deoxyadenosyl-B12 ?
2.5.1.17 ATP + cob(I)alamin
-
Clostridium tetanomorphum triphosphate + coenzyme B12 adenosylcobalamin, B12-coenzyme or deoxyadenosyl-B12 r
2.5.1.17 cyanocob(I)alamin + ATP
-
Clostridium tetanomorphum tripolyphosphate + alpha-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide
-
?
2.5.1.17 additional information UTP, GTP, ITP are poor substrates Clostridium tetanomorphum ?
-
?
2.5.1.17 additional information S-adenosylmethionine, vitamin B12r or B12a, AMP, ADP are no substrates Clostridium tetanomorphum ?
-
?
2.5.1.17 additional information hydroxocobamides or cyanocobamides in which benzimidazole replaces 5,6-dimethylbenzimidazole, or cyanocobamide in which an adenine group replaces 5,6-dimethylbenzimidazole, can also act as substrates Propionibacterium freudenreichii subsp. shermanii ?
-
?
2.5.1.17 additional information hydroxocobamides or cyanocobamides in which benzimidazole replaces 5,6-dimethylbenzimidazole, or cyanocobamide in which an adenine group replaces 5,6-dimethylbenzimidazole, can also act as substrates Clostridium tetanomorphum ?
-
?