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Literature summary extracted from

  • Fabianowska-Majewska, K.; Duley, J.; Fairbanks, L.; Simmonds, A.; Wasiak, T.
    Substrate specificity of methylthioadenosine phosphorylase from human liver (1994), Acta Biochim. Pol., 41, 391-395.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.28 5'-deoxy-adenosine and analogues; strong, competitive Homo sapiens
2.4.2.28 adenine competitive; strong Homo sapiens
2.4.2.28 adenosine strong, competitive Homo sapiens
2.4.2.28 guanine weak Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.28 additional information
-
 additional information
-
 Homo sapiens
2.4.2.28 0.0043
-
 5'-deoxyadenosine
-
 Homo sapiens
2.4.2.28 0.013
-
 5'-methylthioadenosine
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.28 54000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.28 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.28 partial Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.28 S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate phosphorolytic mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.28 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.28 additional information
-
 substrate specificity Homo sapiens
2.4.2.28 0.092
-
 partially purified enzyme, forward reaction, substrate 5'-methylthioadenosine Homo sapiens
2.4.2.28 0.26
-
 substrate 5'-deoxyadenosine, forward reaction Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.28 2'-deoxyadenosine + phosphate low activity Homo sapiens adenine + 2-deoxy-D-ribose 1-phosphate
-
 r
2.4.2.28 2-chloro-2'-deoxyadenosine + phosphate
-
 Homo sapiens 2-chloroadenine + 2-deoxy-D-ribose 1-phosphate
-
 r
2.4.2.28 2-chloro-5'-O-methyl-2'-deoxyadenosine + phosphate
-
 Homo sapiens 2-chloroadenine + 5-O-methyl-2-deoxy-D-ribose 1-phosphate
-
 r
2.4.2.28 2-chloroadenosine + phosphate
-
 Homo sapiens 2-chloroadenine + D-ribose 1-phosphate
-
 r
2.4.2.28 5'-deoxyadenosine + phosphate
-
 Homo sapiens adenine + 5-deoxy-D-ribose 1-phosphate
-
 r
2.4.2.28 5'-iodo-5'-deoxyadenosine + phosphate
-
 Homo sapiens adenine + 5-iodo-5-deoxy-D-ribose 1-phosphate
-
 r
2.4.2.28 5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 r
2.4.2.28 adenosine + phosphate
-
 Homo sapiens adenine + D-ribose 1-phosphate
-
 r