EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.39 | 0.25 | - |
L-2-aminoadipate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
2.6.1.39 | 1 | - |
2-oxoadipate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
2.6.1.39 | 1.1 | - |
2-oxoglutarate | pH 8.0, 37°C isoenzyme AadAT-I | Homo sapiens | |
2.6.1.39 | 1.4 | - |
glutamate | pH 8.0, 37°C | Homo sapiens | |
2.6.1.39 | 2.5 | - |
2-oxoadipate | pH 8.0, 37°C isoenzyme AadAT-I | Homo sapiens | |
2.6.1.39 | 3.2 | - |
2-oxoglutarate | pH 8.0, 37°C isoenzyme AadAT-II | Homo sapiens | |
2.6.1.39 | 12.5 | - |
L-glutamate | pH 8.0, 37°C, isoenzyme AadAT-II | Homo sapiens | |
2.6.1.39 | 20 | - |
L-2-aminoadipate | pH 8.0, 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.6.1.39 | cytoplasm | isoenzyme AadAT-I | Homo sapiens | 5737 | - |
2.6.1.39 | cytosol | - |
Homo sapiens | 5829 | - |
2.6.1.39 | mitochondrion | isoenzyme AadAT-II | Homo sapiens | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.39 | 46000 | - |
2 * 46000, SDS-PAGE | Homo sapiens |
2.6.1.39 | 98000 | - |
isoenzyme AadAT-II, sucrose density gradient centrifugation | Homo sapiens |
2.6.1.39 | 104000 | - |
isoenzyme AadAT-I, sucrose density gradient centrifugation | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.39 | L-2-aminoadipate + 2-oxoglutarate | Homo sapiens | lysine and tryptophan metabolism | 2-oxoadipate + L-glutamate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.39 | Homo sapiens | - |
human | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.39 | 2 isoenzymes, AadAT-I and AadAT-II | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.39 | liver | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.39 | 0.77 | - |
isoenzyme AadAT-I | Homo sapiens |
2.6.1.39 | 10.68 | - |
isoenzyme AadAT-II | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.39 | kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate | - |
ir | |
2.6.1.39 | L-2-aminoadipate + 2-oxoglutarate | - |
Homo sapiens | 2-oxoadipate + L-glutamate | - |
r | |
2.6.1.39 | L-2-aminoadipate + 2-oxoglutarate | lysine and tryptophan metabolism | Homo sapiens | 2-oxoadipate + L-glutamate | - |
r | |
2.6.1.39 | L-tryptophan + 2-oxoglutarate | - |
Homo sapiens | 3-indole-2-oxopropanoate + L-glutamate | - |
? | |
2.6.1.39 | additional information | 2 isoenzymes, AadAT-I and AadAT-II, isoenzyme AadAT-II shows additional activity with tryptophan or kynurenine-2-oxoglutarate reaction, only slight activity with asparagine, alanine, arginine, ornithine, isoleucine, valine, leucine, lysine, serine, threonine, phenylalanine, tyrosine, histidine, glutamine, methionine or aspartate with 2-oxoglutarate | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.6.1.39 | dimer | 2 * 46000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.6.1.39 | AadAT | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.39 | 9 | 9.5 | isoenzyme AadAT-II | Homo sapiens |
2.6.1.39 | 9.5 | - |
isoenzyme AadAT-I | Homo sapiens |
EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.39 | 9 | 9.5 | isoenzyme AadAT-I, sensitive to pH changes, activity is quickly lost at a higher pH, isoenzyme AadAT-II is less sensitive to pH changes | Homo sapiens |